Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 786320..786977 Replicon chromosome
Accession NZ_CP072200
Organism Klebsiella pneumoniae strain B5055

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag J6T75_RS03915 Protein ID WP_002916310.1
Coordinates 786567..786977 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J6T75_RS03910 Protein ID WP_002916312.1
Coordinates 786320..786586 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6T75_RS03885 (J6T75_03875) 781528..782961 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
J6T75_RS03890 (J6T75_03880) 783080..783808 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
J6T75_RS03895 (J6T75_03885) 783858..784169 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
J6T75_RS03900 (J6T75_03890) 784333..784992 + 660 WP_002916317.1 hemolysin III family protein -
J6T75_RS03905 (J6T75_03895) 785091..786074 - 984 WP_016530681.1 tRNA-modifying protein YgfZ -
J6T75_RS03910 (J6T75_03900) 786320..786586 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J6T75_RS03915 (J6T75_03905) 786567..786977 + 411 WP_002916310.1 protein YgfX Toxin
J6T75_RS03920 (J6T75_03910) 786984..787505 - 522 WP_004144730.1 flavodoxin FldB -
J6T75_RS03925 (J6T75_03915) 787606..788502 + 897 WP_046042376.1 site-specific tyrosine recombinase XerD -
J6T75_RS03930 (J6T75_03920) 788525..789238 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J6T75_RS03935 (J6T75_03925) 789244..790977 + 1734 WP_016530103.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T197496 WP_002916310.1 NZ_CP072200:786567-786977 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T197496 NZ_CP096220:c134802-134530 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACATATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT197496 WP_002916312.1 NZ_CP072200:786320-786586 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT197496 NZ_CP096220:c135065-134802 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTTGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References