Detailed information of TA system TA197489

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4764239..4764870
• Replicon: chromosome
• Accession: NZ_CP072199
• Organism: Serratia marcescens subsp. marcescens ATCC 13880

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5C7D7C3
• Locus tag: J6N75_RS22795
• Protein ID: WP_033640020.1
• Coordinates: 4764239..4764637 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J6N75_RS22800
• Protein ID: WP_033640019.1
• Coordinates: 4764637..4764870 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6N75_RS22770 (J6N75_22770)	4759814..4760188	+	375	WP_033640023.1	type II toxin-antitoxin system RelE/ParE family toxin	-
J6N75_RS22775 (J6N75_22775)	4760181..4760483	+	303	WP_015378258.1	DNA-binding transcriptional regulator	-
J6N75_RS22780 (J6N75_22780)	4760486..4760890	-	405	WP_033640022.1	flagellar protein FlhE	-
J6N75_RS22785 (J6N75_22785)	4760890..4762968	-	2079	WP_016927291.1	flagellar biosynthesis protein FlhA	-
J6N75_RS22790 (J6N75_22790)	4762961..4764112	-	1152	WP_033640021.1	flagellar biosynthesis protein FlhB	-
J6N75_RS22795 (J6N75_22795)	4764239..4764637	-	399	WP_033640020.1	type II toxin-antitoxin system VapC family toxin	Toxin
J6N75_RS22800 (J6N75_22800)	4764637..4764870	-	234	WP_033640019.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
J6N75_RS22805 (J6N75_22805)	4765020..4765664	-	645	WP_004934858.1	protein phosphatase CheZ	-
J6N75_RS22810 (J6N75_22810)	4765675..4766064	-	390	WP_004934862.1	chemotaxis response regulator CheY	-
J6N75_RS22815 (J6N75_22815)	4766167..4767216	-	1050	WP_033640018.1	chemotaxis response regulator protein-glutamate methylesterase	-
J6N75_RS22820 (J6N75_22820)	4767216..4768088	-	873	WP_025159837.1	protein-glutamate O-methyltransferase CheR	-
J6N75_RS22825 (J6N75_22825)	4768126..4769742	-	1617	WP_033640017.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14918.11 Da
• Isoelectric Point: 8.4955

>T197489 WP_033640020.1 NZ_CP072199:c4764637-4764239 [Serratia marcescens subsp. marcescens ATCC 13880]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Nucleotide

• Length: 399 bp

>T197489 NZ_CP096211:1205357-1205539 [Enterococcus faecium]
ATGCCAATGACGCAAAATGAAATGGTGAAACTCCTAATTGAACACGGCGGCGTTAAAGTCAAAGGTGGGAAAGGATCTCA
TATAAAAGTGAGGTTTCCTGGAGTGAACCGGCCGATCATTGTTCCTCAGAAATTACCCAAAGGGACAGAAAACGGTATTT
TGAAGCAAGCAGGGTTGAAATAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8799.82 Da
• Isoelectric Point: 5.0789

>AT197489 WP_033640019.1 NZ_CP072199:c4764870-4764637 [Serratia marcescens subsp. marcescens ATCC 13880]
MTLGSVFTNNRTQAVRLPAEARFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREAF

Nucleotide

• Length: 234 bp

>AT197489 NZ_CP096211:1205577-1206032 [Enterococcus faecium]
ATGCTTGTTTCTTATCCGGCCTTGTTCTATTTCGAAAATAGCGAAGGCTATGACCCTGGATTTTCTGTTTTCTTTCCAGA
CTTTCCCAATACAGGTGGTACGAGTGGTTCTACAATCTCTGAAGCTCTGGAAATGGCGTCTGATTATTTAGGAATTTTAT
TATCTGATGATATTGAACAGGAACGCGAGTTACCAAAACCTTCCTTAATCAGTTCGCTATCTTTAGAAGAGAATGATCCT
TTTAAAGATGATTCAGATTTTAATTTTGAATATGATTTTGAAAAATCGTTTGTGTCTATGGTGAGTGTTGATCTATCCCA
ATATCTTGGGAATAATGATCCCATTAAAAAGACTTTAACTATTCCCAAGTGGGCAGATAAGCTTGGAAAGGATCTTCATT
TGAACTTTTCAAAGACTTTAACTGATGCAATCGTAAGCAAAAAAATGGGTGCATAA

Structures

Toxin

• AlphaFold DB: A0A5C7D7C3