Detailed information of TA system TA197478

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1710148..1710683
• Replicon: chromosome
• Accession: NZ_CP072199
• Organism: Serratia marcescens subsp. marcescens ATCC 13880

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D971
• Locus tag: J6N75_RS08160
• Protein ID: WP_033636570.1
• Coordinates: 1710408..1710683 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G2GBD7
• Locus tag: J6N75_RS08155
• Protein ID: WP_033639076.1
• Coordinates: 1710148..1710408 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6N75_RS08135 (J6N75_08135)	1705476..1706126	+	651	WP_033639079.1	DcrB-related protein	-
J6N75_RS08140 (J6N75_08140)	1706162..1706767	+	606	WP_004934025.1	glutathione S-transferase	-
J6N75_RS08145 (J6N75_08145)	1706833..1708227	+	1395	WP_033639078.1	L-seryl-tRNA(Sec) selenium transferase	-
J6N75_RS08150 (J6N75_08150)	1708224..1710065	+	1842	WP_033639077.1	selenocysteine-specific translation elongation factor	-
J6N75_RS08155 (J6N75_08155)	1710148..1710408	+	261	WP_033639076.1	ribbon-helix-helix domain-containing protein	Antitoxin
J6N75_RS08160 (J6N75_08160)	1710408..1710683	+	276	WP_033636570.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J6N75_RS08165 (J6N75_08165)	1710695..1711606	-	912	WP_033639075.1	LysR family transcriptional regulator	-
J6N75_RS08170 (J6N75_08170)	1711728..1712354	+	627	WP_033639074.1	LysE family translocator	-
J6N75_RS08175 (J6N75_08175)	1712408..1713655	-	1248	WP_028127797.1	MFS transporter	-
J6N75_RS08180 (J6N75_08180)	1713873..1714865	+	993	WP_033639073.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10578.32 Da
• Isoelectric Point: 10.3377

>T197478 WP_033636570.1 NZ_CP072199:1710408-1710683 [Serratia marcescens subsp. marcescens ATCC 13880]
MELKWTSKALSDLARLFEFLALANRTAAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T197478 NZ_CP096205:c1496931-1496650 [Flavobacterium azooxidireducens]
GTGATTAAAAGTTTTACATGTAAAGAAACGGAGAAAATTTGGAACGGAATTCAATCCAGAAAACTTCCTTCTGACATTCA
AAATGTAGCCAGAAGAAAATTAAGAATGATTAATAATGCTCAAAACATAAATGATTTAAGGATTCCACCTGCAAACCATT
TAGAAAAATTAAGCGGAAATCTTGAAGGATTTCATAGTATCAGAATTAATAAACAATGGCGAATAATTTTTAGGTGGGAA
AATGACAATGCTTTAGAAGTAGAAATTATAGATTATCATTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9682.01 Da
• Isoelectric Point: 4.5317

>AT197478 WP_033639076.1 NZ_CP072199:1710148-1710408 [Serratia marcescens subsp. marcescens ATCC 13880]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDE
PLPVPR

Nucleotide

• Length: 261 bp

>AT197478 NZ_CP096205:c1496638-1496339 [Flavobacterium azooxidireducens]
ATGGCAACTTTAAAAAACATACATCCCGGTGAAATATTAAAAGAAGAATTTCTTGTTCCACTTGAAATATCAGCATACCG
TTTATCAAAAGAAACGTTTATTCCTCAAACTCGCATAAGCGAAATTATTAAAGGAAACAGAAGAATTACTGCAGATACAG
CCTTGCGATTATCAAAATACTTTAGTACCACTGCCAAGTTTTGGTTAGGTTTACAAGATGATTATGATATTGAAGAAGAA
AAAATGGCTAAAAAAACAGAATTGGATAGTATTCAACCGATGAATACGGATGCGGCTTAG

Structures

Toxin

• AlphaFold DB: A0A5C7D971