Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 991751..992346 | Replicon | chromosome |
| Accession | NZ_CP072199 | ||
| Organism | Serratia marcescens subsp. marcescens ATCC 13880 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A1S6LRI1 |
| Locus tag | J6N75_RS04735 | Protein ID | WP_071605322.1 |
| Coordinates | 992092..992346 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | J6N75_RS04730 | Protein ID | WP_223294898.1 |
| Coordinates | 991751..992095 (-) | Length | 115 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6N75_RS04710 (J6N75_04710) | 987259..988074 | - | 816 | WP_033639337.1 | GPO family capsid scaffolding protein | - |
| J6N75_RS04715 (J6N75_04715) | 988217..989989 | + | 1773 | WP_033639336.1 | terminase ATPase subunit family protein | - |
| J6N75_RS04720 (J6N75_04720) | 989989..990675 | + | 687 | WP_060445964.1 | terminase family protein | - |
| J6N75_RS04725 (J6N75_04725) | 990672..991706 | + | 1035 | WP_033639335.1 | phage portal protein | - |
| J6N75_RS04730 (J6N75_04730) | 991751..992095 | - | 345 | WP_223294898.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| J6N75_RS04735 (J6N75_04735) | 992092..992346 | - | 255 | WP_071605322.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| J6N75_RS04740 (J6N75_04740) | 992716..992913 | - | 198 | WP_126186641.1 | hypothetical protein | - |
| J6N75_RS04745 (J6N75_04745) | 992961..993143 | - | 183 | WP_227944620.1 | hypothetical protein | - |
| J6N75_RS04750 (J6N75_04750) | 993224..995440 | - | 2217 | WP_033639332.1 | replication endonuclease | - |
| J6N75_RS04755 (J6N75_04755) | 995437..995751 | - | 315 | WP_033639331.1 | DUF3850 domain-containing protein | - |
| J6N75_RS04760 (J6N75_04760) | 995765..995938 | - | 174 | WP_162531492.1 | hypothetical protein | - |
| J6N75_RS04765 (J6N75_04765) | 995878..996102 | - | 225 | WP_033639330.1 | TraR/DksA C4-type zinc finger protein | - |
| J6N75_RS04770 (J6N75_04770) | 996102..996344 | - | 243 | WP_023447523.1 | DUF2732 family protein | - |
| J6N75_RS04775 (J6N75_04775) | 996408..996710 | - | 303 | WP_031221632.1 | hypothetical protein | - |
| J6N75_RS04780 (J6N75_04780) | 996722..996901 | - | 180 | WP_072009648.1 | DUF2724 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 963157..999939 | 36782 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9495.97 Da Isoelectric Point: 11.1073
>T197476 WP_071605322.1 NZ_CP072199:c992346-992092 [Serratia marcescens subsp. marcescens ATCC 13880]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP
Download Length: 255 bp
>T197476 NZ_CP096201:4607209-4607586 [Kluyvera ascorbata]
GTGCAAACCCAACCACTATCCTCCACGCATGAGACCTCACCACGTCCGTCCCCCGTGGATATCTGGCAGCACCTCCTGAA
CCATCTGCTGGATCGTCACTACGGTCTGACGCTAAACGACACGCCATTTGGCAACGATGGCGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAACTTTATCGTGGAAAAGTACGACCTGGTCCGTACTGACAGACGCGGCTTT
AGCGCAGACACACAGTCACCGCTTATCGGCAGTATTGATATCCTCCGAGCCCGGAAGGCGACCGGGCTGATGACCCGTCA
TGGCTACAGACCTGTGACAGATCTCATTACCGGCAAATACAAAAAGGAACAACAATGA
GTGCAAACCCAACCACTATCCTCCACGCATGAGACCTCACCACGTCCGTCCCCCGTGGATATCTGGCAGCACCTCCTGAA
CCATCTGCTGGATCGTCACTACGGTCTGACGCTAAACGACACGCCATTTGGCAACGATGGCGTGATCCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAACTTTATCGTGGAAAAGTACGACCTGGTCCGTACTGACAGACGCGGCTTT
AGCGCAGACACACAGTCACCGCTTATCGGCAGTATTGATATCCTCCGAGCCCGGAAGGCGACCGGGCTGATGACCCGTCA
TGGCTACAGACCTGTGACAGATCTCATTACCGGCAAATACAAAAAGGAACAACAATGA
Antitoxin
Download Length: 115 a.a. Molecular weight: 12531.10 Da Isoelectric Point: 4.5789
>AT197476 WP_223294898.1 NZ_CP072199:c992095-991751 [Serratia marcescens subsp. marcescens ATCC 13880]
MMNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLS
PERHQALAIAAQATGQSINELLNEGVDLVIEKHS
MMNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLS
PERHQALAIAAQATGQSINELLNEGVDLVIEKHS
Download Length: 345 bp
>AT197476 NZ_CP096201:4606798-4607157 [Kluyvera ascorbata]
TTGTCGAATAAAATACCGGCAGAAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGTGCCCGTCTGGTGCAGGAGGGCAACCGGCTGCACTATCTCGCCGACCGCGCGAGTATCGCCGGCACGTTCAGCGACG
CGGATTTACGCCATCTTGACCAGGCGTTTCCGGTACAGCTCAAACAGCTTGAGCTGATGCTGGTTTCCGGTGAACTCAAT
CCCCGCCATCAGCACTGCGTCACATTATACTCAAAAGGGCTGACCTGCGAGGCCGACAGCCTCGGCTCGCATGGATACGT
GTACATCGCGATTTACCCGACACCTGCAGCAACCGCGTAA
TTGTCGAATAAAATACCGGCAGAAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGTGCCCGTCTGGTGCAGGAGGGCAACCGGCTGCACTATCTCGCCGACCGCGCGAGTATCGCCGGCACGTTCAGCGACG
CGGATTTACGCCATCTTGACCAGGCGTTTCCGGTACAGCTCAAACAGCTTGAGCTGATGCTGGTTTCCGGTGAACTCAAT
CCCCGCCATCAGCACTGCGTCACATTATACTCAAAAGGGCTGACCTGCGAGGCCGACAGCCTCGGCTCGCATGGATACGT
GTACATCGCGATTTACCCGACACCTGCAGCAACCGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|