Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 701777..702446 Replicon chromosome
Accession NZ_CP072199
Organism Serratia marcescens subsp. marcescens ATCC 13880

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag J6N75_RS03375 Protein ID WP_016929976.1
Coordinates 701777..702199 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag J6N75_RS03380 Protein ID WP_004931679.1
Coordinates 702180..702446 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6N75_RS03355 (J6N75_03355) 697663..698181 + 519 WP_033639477.1 flavodoxin FldB -
J6N75_RS03360 (J6N75_03360) 698219..699583 - 1365 WP_033639476.1 cell envelope integrity protein CreD -
J6N75_RS03365 (J6N75_03365) 699664..701082 - 1419 WP_033639474.1 two-component system sensor histidine kinase CreC -
J6N75_RS03370 (J6N75_03370) 701079..701777 - 699 WP_033639472.1 two-component system response regulator CreB -
J6N75_RS03375 (J6N75_03375) 701777..702199 - 423 WP_016929976.1 protein YgfX Toxin
J6N75_RS03380 (J6N75_03380) 702180..702446 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
J6N75_RS03385 (J6N75_03385) 702767..703759 + 993 WP_033639470.1 tRNA-modifying protein YgfZ -
J6N75_RS03390 (J6N75_03390) 703798..704295 - 498 WP_033639468.1 DUF2165 domain-containing protein -
J6N75_RS03395 (J6N75_03395) 704446..705120 - 675 WP_033639467.1 hemolysin III family protein -
J6N75_RS03400 (J6N75_03400) 705304..705912 + 609 WP_028127691.1 HD domain-containing protein -
J6N75_RS03405 (J6N75_03405) 705953..706879 - 927 WP_033639466.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16501.62 Da        Isoelectric Point: 11.2159

>T197475 WP_016929976.1 NZ_CP072199:c702199-701777 [Serratia marcescens subsp. marcescens ATCC 13880]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLHPPAGNGEEP

Download         Length: 423 bp

>T197475 NZ_CP096201:c4440277-4439993 [Kluyvera ascorbata]
ATGACCTATGAGCTGGAATTTGATCCTCGTGCGCTTCGGGAGTGGCATAAGCTCGGTGAAACGGTAAAAGCACAGTTTAA
AAGCCGTTTGGCAAAGGTGTTAGAGAATCCACGAATACCCTCAGCCAGGCTGCATGAATTTCCTGACTGCTACAAAATAA
AGCTCAAATCATCCGGGTATCGCCTGGTATATCAGGTTCGCGACGACGTCGTGGTCGTCTTTGTTATCGCGGTGGGAAAA
CGAGAAAGGTCAGCCGTTTATCGGGACGCGCATAAACGGCTGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT197475 WP_004931679.1 NZ_CP072199:c702446-702180 [Serratia marcescens subsp. marcescens ATCC 13880]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT197475 NZ_CP096201:c4440509-4440267 [Kluyvera ascorbata]
ATGGCCACGCTCAACGTCCGACTGGACGATAATCTCAAAAAAGAGGCTTATGCCGTGCTGGAAAAACTCGATATCACGCC
AACCGAAGCCGTTCGTCTTCTCTTTCAGTACGTTGCCGAAAATGGGCGCATGCCGGTAAAAACGGTGACCATTAGCGATA
GCGAAGAGGCGCTGCTGCAAAGCGTTCGCGAGCGTCTGGCTAATCCGGAGAAGGGCATTAAGGTTAGCCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References