Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 324083..324739 Replicon chromosome
Accession NZ_CP072199
Organism Serratia marcescens subsp. marcescens ATCC 13880

Toxin (Protein)


Gene name vapC Uniprot ID A0A379YUY4
Locus tag J6N75_RS01590 Protein ID WP_033639649.1
Coordinates 324083..324472 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A379YUX3
Locus tag J6N75_RS01595 Protein ID WP_033639648.1
Coordinates 324476..324739 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6N75_RS01575 (J6N75_01575) 320551..321981 + 1431 WP_033639650.1 multidrug transporter subunit MdtD -
J6N75_RS01580 (J6N75_01580) 321978..323360 + 1383 WP_016926705.1 two-component system sensor histidine kinase BaeS -
J6N75_RS01585 (J6N75_01585) 323360..324076 + 717 WP_004941568.1 two-component system response regulator BaeR -
J6N75_RS01590 (J6N75_01590) 324083..324472 - 390 WP_033639649.1 type II toxin-antitoxin system VapC family toxin Toxin
J6N75_RS01595 (J6N75_01595) 324476..324739 - 264 WP_033639648.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J6N75_RS01600 (J6N75_01600) 325078..325416 + 339 WP_016926703.1 YegP family protein -
J6N75_RS01605 (J6N75_01605) 325595..326947 + 1353 WP_028127781.1 tRNA 5-hydroxyuridine modification protein YegQ -
J6N75_RS01610 (J6N75_01610) 327415..328320 + 906 WP_016926701.1 lipid kinase YegS -
J6N75_RS01615 (J6N75_01615) 328489..329703 + 1215 WP_033639647.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14324.57 Da        Isoelectric Point: 7.8794

>T197474 WP_033639649.1 NZ_CP072199:c324472-324083 [Serratia marcescens subsp. marcescens ATCC 13880]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RATMERKGKIMGAIDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T197474 NZ_CP096201:3765050-3765268 [Kluyvera ascorbata]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGCCTAAGACGCTGTCAGTCAATTGATACGCTGGAGCGTGT
CATTGAAAAAAATAAATATGAATTGTCCGATAACGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTGGCCGAGT
TAACCATGAATAAATTGTACGACAAAATTCCTTCGACCGTCTGGAAGTTCATCCGTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10094.37 Da        Isoelectric Point: 4.6702

>AT197474 WP_033639648.1 NZ_CP072199:c324739-324476 [Serratia marcescens subsp. marcescens ATCC 13880]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGMADR
DPFSEEE

Download         Length: 264 bp

>AT197474 NZ_CP096201:3764650-3765024 [Kluyvera ascorbata]
ATGGACGAATACTCACCAAAAAGACACGATATCGCACAGCTTAAGTTTCTTTGTGAAACCCTGTATCATGACTGTCTTGT
CACGCTTGAAGAGAGCAACCATGGCTGGGTGAATGACCCTACCTCGGCGGTTAACCTGCAGCTTAATGAGCTGATTGAAC
ATATTGCAACGTTTGCACTTAATTATAAAATTAAGTACGACGAAGATAATAAATTGATTGCACAGATCGACGAATATCTG
GATGATACTTTTATGTTGTTCAGTAACTACGGCATTAATAGCAGCGACCTGCAAAAATGGCGTAAGTCAGGGAACAAACT
TTTCCGCTGTTTCGTCAACGCTAGCCGAGCTAACCCTGTTAGCCTCTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A379YUY4

Antitoxin

Source ID Structure
AlphaFold DB A0A379YUX3

References