Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yoeB-Axe/YoeB-RelB |
| Location | 2115833..2116365 | Replicon | chromosome |
| Accession | NZ_CP072197 | ||
| Organism | Lactobacillus crispatus strain ATCC 33820 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | - |
| Locus tag | J6L97_RS10370 | Protein ID | WP_057727062.1 |
| Coordinates | 2115833..2116093 (-) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | Axe | Uniprot ID | V5E284 |
| Locus tag | J6L97_RS10375 | Protein ID | WP_013087009.1 |
| Coordinates | 2116090..2116365 (-) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6L97_RS10345 (J6L97_10345) | 2111241..2112056 | + | 816 | WP_057727003.1 | bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase | - |
| J6L97_RS10350 (J6L97_10350) | 2112385..2112927 | - | 543 | WP_057727004.1 | hypothetical protein | - |
| J6L97_RS10355 (J6L97_10355) | 2113291..2114124 | - | 834 | WP_057727006.1 | helix-turn-helix transcriptional regulator | - |
| J6L97_RS10360 (J6L97_10360) | 2114331..2115188 | + | 858 | WP_118992340.1 | IS982-like element ISLh1 family transposase | - |
| J6L97_RS10365 (J6L97_10365) | 2115231..2115850 | + | 620 | Protein_2002 | IS982 family transposase | - |
| J6L97_RS10370 (J6L97_10370) | 2115833..2116093 | - | 261 | WP_057727062.1 | Txe/YoeB family addiction module toxin | Toxin |
| J6L97_RS10375 (J6L97_10375) | 2116090..2116365 | - | 276 | WP_013087009.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| J6L97_RS10380 (J6L97_10380) | 2116561..2116692 | - | 132 | WP_041811095.1 | hypothetical protein | - |
| J6L97_RS10385 (J6L97_10385) | 2116804..2117214 | + | 411 | WP_054833074.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| J6L97_RS10390 (J6L97_10390) | 2117220..2117474 | + | 255 | WP_223876398.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J6L97_RS10395 (J6L97_10395) | 2117584..2118270 | + | 687 | WP_054833073.1 | cobalamin biosynthesis protein CobQ | - |
| J6L97_RS10400 (J6L97_10400) | 2118315..2118800 | - | 486 | WP_013087013.1 | C40 family peptidase | - |
| J6L97_RS10405 (J6L97_10405) | 2118981..2119838 | - | 858 | WP_118992340.1 | IS982-like element ISLh1 family transposase | - |
| J6L97_RS10410 (J6L97_10410) | 2119969..2120319 | + | 351 | WP_054832808.1 | hypothetical protein | - |
| J6L97_RS10415 (J6L97_10415) | 2120440..2121318 | + | 879 | WP_013087015.1 | helix-turn-helix transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 2114331..2119838 | 5507 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10251.84 Da Isoelectric Point: 9.9171
>T197473 WP_057727062.1 NZ_CP072197:c2116093-2115833 [Lactobacillus crispatus]
MIVAWTDDGWNDYVYWYDDGDYKKVSRINDLVKDMKRHPFTGIGKPEPLKRNLSGLWSRRIDSKNRIVYDCHKSMITIRV
VLVKSF
MIVAWTDDGWNDYVYWYDDGDYKKVSRINDLVKDMKRHPFTGIGKPEPLKRNLSGLWSRRIDSKNRIVYDCHKSMITIRV
VLVKSF
Download Length: 261 bp
>T197473 NZ_CP096201:3387627-3388007 [Kluyvera ascorbata]
ATGACTATCTATAAGGCAAAACGATTCAACCAAAACACCAAAAAGCTTGGCATCACGGACGACGTGCTATTGAAAGCTGC
CGAAGATATCAAACAGGGTGTTTGGGAAGCGAATTTAGGCGGGGGGGTAATCAAAAAGCGCCTGCCTCTGCAGCAAGGCA
AAAGCGGTGGCGCAAGAACCGTCATCTTTTTCAAATACGATCGACATATTTTTTTCTACGATGGTTGGGCGAAAAATAGT
GTCAGTAGTGGAAATGGTAAAGAAATAGAGGATGACGAACTTATTGCTTATCGAAAGCTGGCTAGCGCTTTTTTAGCATT
CACTGATAAGGATATCGCAAAACTCCTGATCACCGGTTTTTTAGTTGAGGTAGATAAATGA
ATGACTATCTATAAGGCAAAACGATTCAACCAAAACACCAAAAAGCTTGGCATCACGGACGACGTGCTATTGAAAGCTGC
CGAAGATATCAAACAGGGTGTTTGGGAAGCGAATTTAGGCGGGGGGGTAATCAAAAAGCGCCTGCCTCTGCAGCAAGGCA
AAAGCGGTGGCGCAAGAACCGTCATCTTTTTCAAATACGATCGACATATTTTTTTCTACGATGGTTGGGCGAAAAATAGT
GTCAGTAGTGGAAATGGTAAAGAAATAGAGGATGACGAACTTATTGCTTATCGAAAGCTGGCTAGCGCTTTTTTAGCATT
CACTGATAAGGATATCGCAAAACTCCTGATCACCGGTTTTTTAGTTGAGGTAGATAAATGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10597.82 Da Isoelectric Point: 4.5716
>AT197473 WP_013087009.1 NZ_CP072197:c2116365-2116090 [Lactobacillus crispatus]
MDAVNYSNFRKNLKHYFKQVNDDSEPLIVTNKEPEDNVVVLGKEDYDALVETLEIQSNQYLMDKIERGRKQVSEGTIKQH
ELIDPEQVTKS
MDAVNYSNFRKNLKHYFKQVNDDSEPLIVTNKEPEDNVVVLGKEDYDALVETLEIQSNQYLMDKIERGRKQVSEGTIKQH
ELIDPEQVTKS
Download Length: 276 bp
>AT197473 NZ_CP096201:3388004-3388333 [Kluyvera ascorbata]
ATGACTAACAAACTCAAAACAATACTTGATGACGCTAAAGAGCTTAACGCACTTGGCCTGATGCCAGAGAACGATGTTGC
TGAAATCAATAAGCTTTTAAAAGCGCGCGAGCTTAAAACACGTATCGCCGCCGTTAAGATGATGTCTGGTGAAGAGATTA
AGGCGGTTCGTGCTCGTTTCGGTATGTCGCAGTCTATTTTGGCGCACACGCTGGGAATGTCTAAAGAGAGCGTGTCCAAA
TGGGAGCGCAACGAAATCAAACCCAGCGGTCCAGCGTTACGTATTCTCAATACTTTGGCCGCCAAAGGCCCGGAAGTATT
CACTAAGTAA
ATGACTAACAAACTCAAAACAATACTTGATGACGCTAAAGAGCTTAACGCACTTGGCCTGATGCCAGAGAACGATGTTGC
TGAAATCAATAAGCTTTTAAAAGCGCGCGAGCTTAAAACACGTATCGCCGCCGTTAAGATGATGTCTGGTGAAGAGATTA
AGGCGGTTCGTGCTCGTTTCGGTATGTCGCAGTCTATTTTGGCGCACACGCTGGGAATGTCTAAAGAGAGCGTGTCCAAA
TGGGAGCGCAACGAAATCAAACCCAGCGGTCCAGCGTTACGTATTCTCAATACTTTGGCCGCCAAAGGCCCGGAAGTATT
CACTAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|