Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1146273..1146943 Replicon plasmid unnamed1
Accession NZ_CP072173
Organism Rhizobium sp. AB2/73

Toxin (Protein)


Gene name vapC Uniprot ID A0A1E4Y5D1
Locus tag J5284_RS24980 Protein ID WP_069614530.1
Coordinates 1146273..1146677 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1E4Y5E1
Locus tag J5284_RS24985 Protein ID WP_069614531.1
Coordinates 1146674..1146943 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5284_RS24965 (J5284_24965) 1143037..1144449 - 1413 WP_069614527.1 XRE family transcriptional regulator -
J5284_RS24970 (J5284_24970) 1144655..1145944 + 1290 WP_069614528.1 isocitrate lyase -
J5284_RS24975 (J5284_24975) 1145971..1146216 + 246 WP_069614529.1 hypothetical protein -
J5284_RS24980 (J5284_24980) 1146273..1146677 - 405 WP_069614530.1 type II toxin-antitoxin system VapC family toxin Toxin
J5284_RS24985 (J5284_24985) 1146674..1146943 - 270 WP_069614531.1 antitoxin Antitoxin
J5284_RS24990 (J5284_24990) 1147108..1148067 - 960 WP_069614532.1 asparaginase -
J5284_RS24995 (J5284_24995) 1148064..1149515 - 1452 WP_069614533.1 amino acid permease -
J5284_RS25000 (J5284_25000) 1149790..1151217 + 1428 WP_069614534.1 aspartate ammonia-lyase -
J5284_RS25005 (J5284_25005) 1151189..1151902 - 714 WP_069614535.1 FadR/GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..1332287 1332287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(18-56)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14308.68 Da        Isoelectric Point: 5.1871

>T197467 WP_069614530.1 NZ_CP072173:c1146677-1146273 [Rhizobium sp. AB2/73]
MSKLYMLDTNIVSELARNPQGIVARRIADVGPDAICVSIITAAELRYGCAKKGSPKLLAQIEAILGSIPVLALDVPADAE
YGAIRAELEVAGKPIGPNDLLIAAHAHALEAVLVTANIGEFKRVRDLRVENWLD

Download         Length: 405 bp

>T197467 NZ_CP096201:904509-904832 [Kluyvera ascorbata]
ATGAAATCTCAACCTGCAACAACTCAGCGGGCGGCGAAGCCCTGCCTGTCACCCGTGGATGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTCACCCTCAACGACACACCATTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGTATCACGCTGGCTGATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGATTATTGATATCATGAGGGCCCGCCTGGATCTGGGTTTATTAAATCGTAA
TTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10269.78 Da        Isoelectric Point: 5.6560

>AT197467 WP_069614531.1 NZ_CP072173:c1146943-1146674 [Rhizobium sp. AB2/73]
MRHLRHNEPSPPREAKLFRNNKSQAVRIPADFELPGDRVMIHREGDRLIIEPVRRKSLLDVLASLEPLGPEDQFPDIDDT
LLPAKEIEL

Download         Length: 270 bp

>AT197467 NZ_CP096201:904171-904488 [Kluyvera ascorbata]
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTACAGGAGGGGAACCGGCT
GCATTATTTAGCTGAACGGGCCAGCATCACCGGCCAGTTCAGTGACGCAGAATGCCGGAAGCTGGATGTGGCATTTCCGT
ACTTTATCCGCCAGATGGAATCCATGCTGACTACCGGTGAACTGAATCCTCGCCACACCCACTGCGTCACTCTGTACCGC
AACGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATATATCGCCATTTATCCCACTCAGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E4Y5D1

Antitoxin

Source ID Structure
AlphaFold DB A0A1E4Y5E1

References