Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 884333..885009 Replicon plasmid unnamed1
Accession NZ_CP072173
Organism Rhizobium sp. AB2/73

Toxin (Protein)


Gene name vapC Uniprot ID A0A1E4Y2Q6
Locus tag J5284_RS23855 Protein ID WP_069615564.1
Coordinates 884587..885009 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1E4Y2P7
Locus tag J5284_RS23850 Protein ID WP_069615565.1
Coordinates 884333..884590 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5284_RS23830 (J5284_23830) 879550..880962 + 1413 WP_069615702.1 ROK family protein -
J5284_RS23835 (J5284_23835) 881191..882180 + 990 WP_069615568.1 substrate-binding domain-containing protein -
J5284_RS23840 (J5284_23840) 882289..883353 + 1065 WP_069615567.1 ribose ABC transporter -
J5284_RS23845 (J5284_23845) 883346..884092 + 747 WP_069615566.1 ATP-binding cassette domain-containing protein -
J5284_RS23850 (J5284_23850) 884333..884590 + 258 WP_069615565.1 plasmid stability protein stbC Antitoxin
J5284_RS23855 (J5284_23855) 884587..885009 + 423 WP_069615564.1 type II toxin-antitoxin system VapC family toxin Toxin
J5284_RS23860 (J5284_23860) 885303..886817 + 1515 WP_069615563.1 histidine ammonia-lyase -
J5284_RS23865 (J5284_23865) 886928..887932 + 1005 WP_069615562.1 ornithine cyclodeaminase family protein -
J5284_RS23870 (J5284_23870) 887978..888754 + 777 WP_069615561.1 PhnD/SsuA/transferrin family substrate-binding protein -
J5284_RS23875 (J5284_23875) 888786..889367 - 582 WP_069615560.1 nucleoside 2-deoxyribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..1332287 1332287


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15359.75 Da        Isoelectric Point: 5.1409

>T197466 WP_069615564.1 NZ_CP072173:884587-885009 [Rhizobium sp. AB2/73]
MIVLDTNVISELWKITPDPNVLSWIDAQMIETLYLSIITVAELRFGLAAMPEGKRRTIYQGRLEREVLPAFANRVLPFDL
DASQAYADLMALARRAGKSIGTADGYIAATAASHGFMVATRDTSPFEAGGLSVINPWNMK

Download         Length: 423 bp

>T197466 NZ_CP096201:868808-869224 [Kluyvera ascorbata]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCTCACAGTGGCTTTCCTTGTTACTCCACGGTCTGGTGGCGGC
TTTCGTGCTGCTGATGCCCTGGCCGTTGAGCTACACCCCGCTCTGGCTGCTTTTGCTCTCTCTGGTGGTCTTTGACTGCG
TTCGCAGCCAGCGACGCATTCATTCGCACCAGGGGGAAATTAAGCTGCTGATGGATTCAAGGCTGCGCTGGCGTAATCAG
GATTACGAACTGCTTGGTGCGCCGTGGATGCTGAATTCAGGGATGATGCTGCGGATTCGTCGTCTGGAAGGAGGCCGTCG
TCAGCACCTGTGGCTGGCGGCAGATAGCATGAATCCTGAAGAGTGGCGTGACCTGCGGCGGATACTTCTGCAACAGCCCA
CGCCAACGAAGCACTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9241.52 Da        Isoelectric Point: 7.2063

>AT197466 WP_069615565.1 NZ_CP072173:884333-884590 [Rhizobium sp. AB2/73]
MASITIRNVSDEVHRAIRVRAAMHGRSTEAEIRDILEKAAKPEGRLKLGSLLTSIAREAGGLTEAEAEGFNQLRDKTPVG
PISFE

Download         Length: 258 bp

>AT197466 NZ_CP096201:868561-868827 [Kluyvera ascorbata]
ATGGACATCAATAATAAAGCCCGTATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATTATGCCGTT
CTTTGAGTACGAGTACGACACGCTCAGCGATGAAGACAAAGCCATTTTCATTCGTCTCCTTGAATGCGACGATCCTGACC
TTTTCAACTGGCTGATGAACCACGGTAAACCTGCCGACGCTAACCTTGAGCGCATGGTACAACTCATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E4Y2Q6

Antitoxin

Source ID Structure
AlphaFold DB A0A1E4Y2P7

References