Detailed information of TA system TA197465

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 3909192..3909672
• Replicon: chromosome
• Accession: NZ_CP072172
• Organism: Rhizobium sp. AB2/73

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: J5284_RS19210
• Protein ID: WP_083258227.1
• Coordinates: 3909192..3909464 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A1E4Y816
• Locus tag: J5284_RS19215
• Protein ID: WP_069613789.1
• Coordinates: 3909448..3909672 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5284_RS19200 (J5284_19195)	3904673..3908134	-	3462	WP_069613792.1	chromosome segregation SMC family protein	-
J5284_RS19205 (J5284_19200)	3908321..3909010	-	690	WP_069613791.1	DsbA family protein	-
J5284_RS19210 (J5284_19205)	3909192..3909464	-	273	WP_083258227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J5284_RS19215 (J5284_19210)	3909448..3909672	-	225	WP_069613789.1	DUF6290 family protein	Antitoxin
J5284_RS19220 (J5284_19215)	3909757..3910251	-	495	WP_069613788.1	DUF721 domain-containing protein	-
J5284_RS19225 (J5284_19220)	3910347..3911462	+	1116	WP_176728026.1	A/G-specific adenine glycosylase	-
J5284_RS19230 (J5284_19225)	3911459..3912073	+	615	WP_069613786.1	HAD family phosphatase	-
J5284_RS19235 (J5284_19230)	3912078..3912443	+	366	WP_069613785.1	nuclear transport factor 2 family protein	-
J5284_RS19240 (J5284_19235)	3912575..3913705	-	1131	WP_069613784.1	site-specific DNA-methyltransferase	-
J5284_RS19245 (J5284_19240)	3913862..3914209	-	348	WP_069613783.1	antibiotic biosynthesis monooxygenase	-
J5284_RS19250 (J5284_19245)	3914206..3914535	-	330	WP_069613782.1	NIPSNAP family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Relaxosome protein TraY (4-49)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10684.37 Da
• Isoelectric Point: 10.3041

>T197465 WP_083258227.1 NZ_CP072172:c3909464-3909192 [Rhizobium sp. AB2/73]
MAWRIEFQRAAERELDKLGHEVSRRILKFLYDRVAKLDDPRAIGEALKGSELGDFWKYRVGDYRIIAHIEDRAVRILIVR
IGNGREVYRK

Nucleotide

• Length: 273 bp

>T197465 NZ_CP096201:c735078-734701 [Kluyvera ascorbata]
ATGCAAACCCGACAACTATCCTCAACGCGGGAGGCCTCACCACGCCCGACGCCCGTTGAAATCTGGCAGACTCTGCTTAC
GTATCTGCTGGAAAGGCATTACGGCCTTTCGCTTAACGACACACAGTTTGGTGATGGCAATGTGATCCATCAGCATATTG
ACGCCGGGATTTCACTGGCAGATGCACTCAATTTTCTCGTTGAAAAGTCTGAACTGGTGCGAATTGATCGTCCCGGTTTC
TCCATTCAGCATCAGTCTCCGTTCATCAGCGCTATTGACATACTCCGGGCCAGAAAGGCCACCGGCCTGATGCAACGTAC
CGGCTATAAGGCGGTGACTTGCGCCATCAGTGGGCAGTCATCCAGGGGGCAGCAATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8519.69 Da
• Isoelectric Point: 4.5593

>AT197465 WP_069613789.1 NZ_CP072172:c3909672-3909448 [Rhizobium sp. AB2/73]
MLALRLPPEIEARLDELAKRTGRSKSFYAREAILEHLDDLEDIYLAEKRLEELRRGESDTVSLAELMARYGVAD

Nucleotide

• Length: 225 bp

>AT197465 NZ_CP096201:c735489-735130 [Kluyvera ascorbata]
ATGCAAAACCCAACAAATGTAGCAAGCCATGATATTACCGAACCCTGGTGGGGGCTTAAGCCTGCAGTCATCCCGTGTTT
TGGCGCACGTCTAGTGCAGGAGGGCAACCGGCTGCATTACCTGGCCGACCGCGCCAGCATTACAGGAACCTTCAGCAATG
CGGATTTACGCCATCTCGACCAGGCGTTTCCGGTTCTGATGAAGCAGCTGGAGCTGATGCTGCTTTCCGGTGAGCTTAAT
CCCCGACATCAGCACTGCGTCACACTGTATGCGAAAGGGCTGACCTGTGAATCAGATACGCTGGGGTCGCATGGGTACGT
GTACCTGGCGATTTATCCGACATCAGCAATAACCGCGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1E4Y816