Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2803013..2803677 Replicon chromosome
Accession NZ_CP072172
Organism Rhizobium sp. AB2/73

Toxin (Protein)


Gene name vapC Uniprot ID A0A1E4Y9V2
Locus tag J5284_RS13640 Protein ID WP_069613021.1
Coordinates 2803013..2803453 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1E4YAE0
Locus tag J5284_RS13645 Protein ID WP_069613201.1
Coordinates 2803450..2803677 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5284_RS13615 (J5284_13620) 2798036..2798878 + 843 WP_069613026.1 RNA methyltransferase -
J5284_RS13620 (J5284_13625) 2798859..2799659 + 801 WP_069613025.1 glutamate racemase -
J5284_RS13625 (J5284_13630) 2799662..2800126 + 465 WP_069613024.1 GNAT family N-acetyltransferase -
J5284_RS13630 (J5284_13635) 2800212..2801357 + 1146 WP_069613023.1 alpha-hydroxy acid oxidase -
J5284_RS13635 (J5284_13640) 2801488..2803005 + 1518 WP_069613022.1 ATP-binding protein -
J5284_RS13640 (J5284_13645) 2803013..2803453 - 441 WP_069613021.1 PIN domain-containing protein Toxin
J5284_RS13645 (J5284_13650) 2803450..2803677 - 228 WP_069613201.1 CopG family transcriptional regulator Antitoxin
J5284_RS13650 (J5284_13655) 2803959..2804576 + 618 WP_069613020.1 30S ribosomal protein S4 -
J5284_RS13655 (J5284_13660) 2804648..2805577 + 930 WP_069613200.1 glutaminase -
J5284_RS13660 (J5284_13665) 2805638..2806525 + 888 WP_069613019.1 tRNA 2-thiocytidine(32) synthetase TtcA -
J5284_RS13665 (J5284_13670) 2806599..2807426 + 828 WP_069613018.1 inositol monophosphatase family protein -
J5284_RS13670 (J5284_13675) 2807443..2808267 + 825 WP_113366607.1 inositol monophosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 15886.09 Da        Isoelectric Point: 6.3690

>T197462 WP_069613021.1 NZ_CP072172:c2803453-2803013 [Rhizobium sp. AB2/73]
VTFLLDVNVLIALFDPSHVSHDIAHEWFHSLGGDSWATCPLTENGVVRILSQPSYPNSPGPPSTAALLVAQLRRLPGHQF
WADDISLLDDTLVDLTRILTPGQITDTYLLALAKFHRGQLATLDRRLSTSAVKDGKAALHIISSNA

Download         Length: 441 bp

>T197462 NZ_CP096200:1049606-1049893 [Vibrio sinaloensis]
ATGAAAGTAGTTTGGTCTCCTTTAGCGCTTCAGAAGCTAGGCGATGCAGCGGAATTTATTTCTTTGGATAATCCATCTGC
CGCAGAAAAGTGGGTGAACGAAGTTTTTGATAAAACTGAACTACTTGGAAGTATGCCTGAAATGGGGCGCTTTGTTCCTG
AAATGCCCCATACGAATTATCGCGAAATCATTTTTGGTCACTATCGTATTATCTACAGCTTAACTCATGAGATCCGCGTA
CTAACAGTACGTAATTGTCGTCAAATGTTGTCGGAAGATGATGTATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8214.41 Da        Isoelectric Point: 8.8566

>AT197462 WP_069613201.1 NZ_CP072172:c2803677-2803450 [Rhizobium sp. AB2/73]
MRTTLAIDDDVLAAAKAMAEQQHRSIGDVISDLARRSLNRSQPAKERNGIPLLTPKTGNPPVTLDLVNKLRDELP

Download         Length: 228 bp

>AT197462 NZ_CP096200:1049328-1049609 [Vibrio sinaloensis]
ATGAGCCGTATTCATTTCGATCAAGATATTCAGCCATTATCTGAATTTCGTGCAGGTGTAGCTTCTTACATCAAACAAAT
CAATGAGACTCGCCGCCCATTGGTGATCACACAACGTGGTAAAGGTGTAGCAGTTGTTCTCGATGTTGCAGAGTATGAAG
CAATGCAAGAGAAAATCGAACTACTAGAAGAAATGCGCACAGCTGAAGCTCAATTAGCTTCAGGTCTTGGTGTTTCCAAT
GATGATGCTCGTGCTCAAGTATTAGGGCGCATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E4Y9V2

Antitoxin

Source ID Structure
AlphaFold DB A0A1E4YAE0

References