Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 469593..470236 Replicon chromosome
Accession NZ_CP072172
Organism Rhizobium sp. AB2/73

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5284_RS02380 Protein ID WP_113366582.1
Coordinates 469832..470236 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5284_RS02375 Protein ID WP_113366583.1
Coordinates 469593..469835 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5284_RS02355 (J5284_02355) 465631..466731 + 1101 WP_069611117.1 DUF917 domain-containing protein -
J5284_RS02360 (J5284_02360) 466750..467079 + 330 WP_069611116.1 TfoX/Sxy family protein -
J5284_RS02365 (J5284_02365) 467122..468783 + 1662 WP_113366585.1 urocanate hydratase -
J5284_RS02370 (J5284_02370) 468853..469527 + 675 WP_113366584.1 hypothetical protein -
J5284_RS02375 (J5284_02375) 469593..469835 + 243 WP_113366583.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J5284_RS02380 (J5284_02380) 469832..470236 + 405 WP_113366582.1 type II toxin-antitoxin system VapC family toxin Toxin
J5284_RS02385 (J5284_02385) 470233..470637 - 405 WP_113366581.1 GFA family protein -
J5284_RS02390 (J5284_02390) 470643..471125 - 483 WP_113366580.1 SRPBCC domain-containing protein -
J5284_RS02395 (J5284_02395) 471109..471450 - 342 WP_113366579.1 metalloregulator ArsR/SmtB family transcription factor -
J5284_RS02400 (J5284_02400) 471542..471928 - 387 WP_069611110.1 VOC family protein -
J5284_RS02405 (J5284_02405) 471943..473226 - 1284 WP_113366578.1 MFS transporter -
J5284_RS02410 (J5284_02410) 473325..474200 + 876 WP_069611108.1 LysR family transcriptional regulator -
J5284_RS02415 (J5284_02415) 474246..475157 - 912 WP_113366577.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14753.00 Da        Isoelectric Point: 8.4869

>T197458 WP_113366582.1 NZ_CP072172:469832-470236 [Rhizobium sp. AB2/73]
VKYLLDSNAIIALMKGHPGFVGKLRRHKPQDFAIPAIVAHELIYGAYKGQRVSDNLARVDALQFETLDFDKQDARVAGEI
RASLASLGTPIGAYDVLIAGQAVARDLILITHNVKEFGRVPKLRFEDWESLPSG

Download         Length: 405 bp

>T197458 NZ_CP096200:c1019509-1019213 [Vibrio sinaloensis]
ATGCAGAAGAATAAGTACAAATTAAGTAAACTAGCTCAGGCTCATTTGCGAAAGATCAGAAGTTATACCGTCAACAATTT
TTCTGAAATGCAGTGGCGCAACTATAAAGATACATTACTAACCGGATTTCAGATGCTTGCGGACAACCCTGCCGTTGGTC
GGAGTTGTGATGAAATTTACCCAAACGGGTTTTACTTTCCTGTAGGCAAACACACAGCTTACTTTACAAAAGAAGACGGT
TTCATTTTAGTCGTAGCTGTACTCGGTCAATCACAACTACCTCAAAACCATTTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9285.42 Da        Isoelectric Point: 4.2296

>AT197458 WP_113366583.1 NZ_CP072172:469593-469835 [Rhizobium sp. AB2/73]
MDTAKIFWSGRSQAVRLPKEFRLDGEEVRIRRQGKAIILEPITEDWDWLEAVTGPVDDDFVEAATEQPAEQQRPELDIFK

Download         Length: 243 bp

>AT197458 NZ_CP096200:c1019758-1019516 [Vibrio sinaloensis]
ATGCACACATTGACAGCAAATGACGCCAAACGTAATTTTGGTGAGTTACTTCTTAGCGCCCAGCGCGAGCCAGTGAAGAT
TAGCAAAAACAGCAAAGATGCCGTGGTTGTAATGTCTATTAGAGACTATGAAGAACTAGAAGCAATGAAAGCAGACTACC
TTAAACATTGTTTCGAGTCAGCTAAGCAAGACTTAGCACAAGGCAATGTCGTTGATGGTGAAGATTTTTTAAACTCCTTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References