Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 172856..173544 Replicon chromosome
Accession NZ_CP072168
Organism Agrobacterium larrymoorei strain AF3.44

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5285_RS15040 Protein ID WP_219276115.1
Coordinates 172856..173278 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5285_RS15045 Protein ID WP_219276117.1
Coordinates 173275..173544 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5285_RS15005 (J5285_15015) 168631..168933 + 303 Protein_151 helix-turn-helix domain-containing protein -
J5285_RS15010 (J5285_15020) 168926..169123 - 198 Protein_152 IS3 family transposase -
J5285_RS15015 (J5285_15025) 169398..169874 + 477 WP_219276107.1 hypothetical protein -
J5285_RS15020 (J5285_15030) 169884..170684 + 801 WP_219276109.1 hypothetical protein -
J5285_RS15025 (J5285_15035) 171088..171384 + 297 WP_219276111.1 PAAR domain-containing protein -
J5285_RS15030 (J5285_15040) 171604..172011 + 408 WP_219276113.1 hypothetical protein -
J5285_RS15035 (J5285_15045) 172141..172710 + 570 WP_235695856.1 hypothetical protein -
J5285_RS15040 (J5285_15050) 172856..173278 - 423 WP_219276115.1 type II toxin-antitoxin system VapC family toxin Toxin
J5285_RS15045 (J5285_15055) 173275..173544 - 270 WP_219276117.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J5285_RS15050 (J5285_15060) 173814..174311 - 498 WP_219276119.1 RES family NAD+ phosphorylase -
J5285_RS15055 (J5285_15065) 174320..174670 - 351 WP_136954379.1 MbcA/ParS/Xre antitoxin family protein -
J5285_RS15060 (J5285_15070) 174903..175349 - 447 WP_027677291.1 hypothetical protein -
J5285_RS15065 (J5285_15075) 175693..176805 + 1113 WP_027677292.1 GSU2403 family nucleotidyltransferase fold protein -
J5285_RS15070 (J5285_15080) 177658..178023 - 366 WP_027677293.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 82210..213703 131493


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-73)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15682.99 Da        Isoelectric Point: 5.6798

>T197454 WP_219276115.1 NZ_CP072168:c173278-172856 [Agrobacterium larrymoorei]
MRLLLDTNILSEVTKPRPNETVLNWLHGLDEDRTFISIVSIAEIRRGDALMDSGKKHDALNEWLTYDLPQRFKNRIIPVE
ELVARAWGDLMALAKRSGRGLASMDGLIGATAVAHQLTLATRNAKDFEGFGIDIIDPWTT

Download         Length: 423 bp

>T197454 NZ_CP096187:c3813570-3813160 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CATTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGTATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTCGGGATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTTTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10054.33 Da        Isoelectric Point: 5.7252

>AT197454 WP_219276117.1 NZ_CP072168:c173544-173275 [Agrobacterium larrymoorei]
MTEVRTHGEINWTVAGAKAKLSEVMERAQLAPQTITRNGKPSVVVVSADEWQRKNERRGSLAEFLLASPLRDADLDLERQ
HDEPRDMSL

Download         Length: 270 bp

>AT197454 NZ_CP096187:c3813817-3813551 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References