Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2071574..2072205 Replicon chromosome
Accession NZ_CP072167
Organism Agrobacterium larrymoorei strain AF3.44

Toxin (Protein)


Gene name vapC Uniprot ID A0A4D7DKT4
Locus tag J5285_RS09850 Protein ID WP_027675859.1
Coordinates 2071807..2072205 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4D7DRW1
Locus tag J5285_RS09845 Protein ID WP_027675860.1
Coordinates 2071574..2071807 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5285_RS09825 (J5285_09830) 2067942..2069159 + 1218 WP_027675864.1 endolytic transglycosylase MltG -
J5285_RS09830 (J5285_09835) 2069217..2070104 + 888 WP_027675863.1 YicC/YloC family endoribonuclease -
J5285_RS09835 (J5285_09840) 2070110..2070781 + 672 WP_027675862.1 guanylate kinase -
J5285_RS09840 (J5285_09845) 2070830..2071489 + 660 WP_084631681.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
J5285_RS09845 (J5285_09850) 2071574..2071807 + 234 WP_027675860.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J5285_RS09850 (J5285_09855) 2071807..2072205 + 399 WP_027675859.1 type II toxin-antitoxin system VapC family toxin Toxin
J5285_RS09855 (J5285_09860) 2072222..2073052 - 831 WP_027675858.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
J5285_RS09860 (J5285_09865) 2073052..2074068 - 1017 WP_027675857.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
J5285_RS09865 (J5285_09870) 2074174..2075115 - 942 WP_027675856.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - acpXL 2061494..2072205 10711


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14862.17 Da        Isoelectric Point: 6.8525

>T197453 WP_027675859.1 NZ_CP072167:2071807-2072205 [Agrobacterium larrymoorei]
MLTYMLDTNICIYVMKTYPPELREKFNALAEQLCISSITLGELYYGAEKSARRTDNIHAIDNFVARLEVLPFADKAAAHY
GQIRAELTKAGTPCGVHDMQIGGHARSEGLIVVTNNMREFVRMPGLRVENWV

Download         Length: 399 bp

>T197453 NZ_CP096187:c2847515-2847412 [Enterobacter roggenkampii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8712.93 Da        Isoelectric Point: 5.8152

>AT197453 WP_027675860.1 NZ_CP072167:2071574-2071807 [Agrobacterium larrymoorei]
MATSTVFISNRSQAVRLPKAVAFPEDVHKVDVLKVGLTRIIVPQGSRWDDLFLSGPKATQDFLERREEPALDERESF

Download         Length: 234 bp

>AT197453 NZ_CP096187:2847405-2847550 [Enterobacter roggenkampii]
AACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D7DKT4

Antitoxin

Source ID Structure
AlphaFold DB A0A4D7DRW1

References