Detailed information of TA system TA197451

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1875747..1876350
• Replicon: chromosome
• Accession: NZ_CP072167
• Organism: Agrobacterium larrymoorei strain AF3.44

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J5285_RS08875
• Protein ID: WP_027676894.1
• Coordinates: 1876123..1876350 (+)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A4D7DQ05
• Locus tag: J5285_RS08870
• Protein ID: WP_027676893.1
• Coordinates: 1875747..1876022 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5285_RS08845 (J5285_08850)	1870789..1871889	-	1101	WP_027676888.1	saccharopine dehydrogenase family protein	-
J5285_RS08850 (J5285_08855)	1872009..1872440	+	432	WP_027676889.1	Lrp/AsnC family transcriptional regulator	-
J5285_RS08855 (J5285_08860)	1872447..1872647	-	201	WP_027676890.1	heavy-metal-associated domain-containing protein	-
J5285_RS08860 (J5285_08865)	1872666..1873085	-	420	WP_027676891.1	Cu(I)-responsive transcriptional regulator	-
J5285_RS08865 (J5285_08870)	1873082..1875601	-	2520	WP_027676892.1	heavy metal translocating P-type ATPase	-
J5285_RS08870 (J5285_08875)	1875747..1876022	+	276	WP_027676893.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
J5285_RS08875 (J5285_08880)	1876123..1876350	+	228	WP_027676894.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
J5285_RS08880 (J5285_08885)	1876355..1877167	-	813	WP_037171690.1	class D beta-lactamase	-
J5285_RS08885 (J5285_08890)	1877343..1878806	-	1464	WP_027676896.1	YdiU family protein	-
J5285_RS08890 (J5285_08895)	1878881..1879594	-	714	WP_084631815.1	YcxB family protein	-
J5285_RS08895 (J5285_08900)	1879818..1880231	-	414	WP_027676899.1	hypothetical protein	-
J5285_RS08900 (J5285_08905)	1880511..1881155	+	645	WP_027676900.1	suppressor of fused domain protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1865756..1880231	14475

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (10-75)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-86)

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8736.95 Da
• Isoelectric Point: 4.9491

>T197451 WP_027676894.1 NZ_CP072167:1876123-1876350 [Agrobacterium larrymoorei]
MNPVVTTWWLKEVMLLSIANDAPLPLNFRDHELTGDWRDHRECHIGGDFLLIYTLDDAQNLIVFTRAGTHSELFR

Nucleotide

• Length: 228 bp

>T197451 NZ_CP096187:c1150882-1150520 [Enterobacter roggenkampii]
ATGTGGAACGTCGAGACAACGGACAGATTTGACGACTGGTTCTTTGAACAAACAACAGCATTAAAAGAAGATGTGCTGGC
GACGATGCATATTCTTGCTGAATTTGGCCCAACCCTGGGGCGACCATACGTAGACACCGTGAAGGATTCAGCCTATGCGA
ACATGAAAGAGTTACGTATTCAGCATGCGGGTAATCCCATCAGAGCCTTTTTTGCCTTTGATCCTGACCGTAAGGCAATT
GTGCTCTGTGCTGGAGACAAAACCGGTTGCAATCAAAAACGGTTTTATAACGAAATGATCGCGCTGGCTGACGTTGAATA
CAGCAGACATCTGGCGGATAAGGAGGCCATATGGCAACGCTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10131.65 Da
• Isoelectric Point: 5.2072

>AT197451 WP_027676893.1 NZ_CP072167:1875747-1876022 [Agrobacterium larrymoorei]
MTANAYVRARIDQEIKDDATAVLDSLGLTVSDVMRMMLTRIAREKALPIELTRPNAETLAAMEEARAIARAKRERFRSAE
EIIDALDGGKQ

Nucleotide

• Length: 276 bp

>AT197451 NZ_CP096187:c1150532-1150233 [Enterobacter roggenkampii]
ATGGCAACGCTAAAAGAACTCATAGCACAACAGAGCGCGGAAAGTCAGGAGCGTATAGCGGCTAAAGTTGAAGTGATGCG
CAGAATTGTTGCCCTGAACCAGCTGCGGGAAGAGCTCAATATTTCCCAGACAGAACTGGCCGCAGCAATGGGGGTAAAAC
AACCCACTTTGGCAAAAATCGAACAGCCGGGAAACGATCCCCGGCTTTCAACACTCAAACGCTATGTCAGTGCGCTCGGC
GGTGAAATGAGCATTGATGTGACGCTACCGAATGGGAAACGGATAGCGTTTCAGATTTGA

Structures

Antitoxin

• AlphaFold DB: A0A4D7DQ05