Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 829654..830221 Replicon chromosome
Accession NZ_CP072167
Organism Agrobacterium larrymoorei strain AF3.44

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J5285_RS03880 Protein ID WP_084631408.1
Coordinates 829654..829815 (+) Length 54 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4D7DJW9
Locus tag J5285_RS03885 Protein ID WP_027673541.1
Coordinates 829820..830221 (+) Length 134 a.a.

Genomic Context

J5285_RS03860J5285_RS03870J5285_RS03875J5285_RS03880J5285_RS03885J5285_RS03865J5285_RS03890J5285_RS03895J5285_RS03900
Location: 826899..827471 (573 bp)
Type: Others
Protein ID: WP_027673546.1
Location: 828293..828976 (684 bp)
Type: Others
Protein ID: WP_027673544.1
Location: 829119..829574 (456 bp)
Type: Others
Protein ID: WP_027673543.1
Location: 829654..829815 (162 bp)
Type: Toxin
Protein ID: WP_084631408.1
Location: 829820..830221 (402 bp)
Type: Antitoxin
Protein ID: WP_027673541.1
Location: 827604..828149 (546 bp)
Type: Others
Protein ID: WP_037170647.1
Location: 830235..831038 (804 bp)
Type: Others
Protein ID: WP_027673540.1
Location: 831127..831801 (675 bp)
Type: Others
Protein ID: WP_027673539.1
Location: 831967..834618 (2652 bp)
Type: Others
Protein ID: WP_027673538.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J5285_RS03860 (J5285_03865)826899..827471+573WP_027673546.1CarD family transcriptional regulator-
J5285_RS03865 (J5285_03870)827604..828149-546WP_037170647.1transpeptidase-
J5285_RS03870 (J5285_03875)828293..828976+684WP_027673544.1response regulator transcription factor-
J5285_RS03875 (J5285_03880)829119..829574+456WP_027673543.1cyclic nucleotide-binding domain-containing protein-
J5285_RS03880 (J5285_03885)829654..829815+162WP_084631408.1type II toxin-antitoxin system HicA family toxinToxin
J5285_RS03885 (J5285_03890)829820..830221+402WP_027673541.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
J5285_RS03890 (J5285_03895)830235..831038-804WP_027673540.1exodeoxyribonuclease III-
J5285_RS03895 (J5285_03900)831127..831801-675WP_027673539.1outer membrane lipoprotein carrier protein LolA-
J5285_RS03900 (J5285_03905)831967..834618-2652WP_027673538.1DNA translocase FtsK-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(11-50)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 5841.95 Da        Isoelectric Point: 11.8222

>T197447 WP_084631408.1 NZ_CP072167:829654-829815 [Agrobacterium larrymoorei]
MKSTDIIAALRKGSHVQFKHASKPGRVTVPHPKRDLPIGTLKSIEKQAGLKLR

Download         Length: 162 bp

>T197447 NZ_CP096187:c290638-290336 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14301.06 Da        Isoelectric Point: 4.6630

>AT197447 WP_027673541.1 NZ_CP072167:829820-830221 [Agrobacterium larrymoorei]
MRNYIGLIHKHADSDYGVSFPDFPGVVTAGTDLDDARLMAEEALSLHVEGLLEDGDAIPEPSSLDDVMKDGENKKAVAIL
VSLKSESKRAVRLNITLPEDVLRDIDAYAQAHGLTRSGFLARAAKHEISSASA

Download         Length: 402 bp

>AT197447 NZ_CP096187:c290329-290042 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACACTCAAACACGCCGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4D7DJW9

References