Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 338028..338624 Replicon chromosome
Accession NZ_CP072167
Organism Agrobacterium larrymoorei strain AF3.44

Toxin (Protein)


Gene name relE Uniprot ID A0A4D7DXW7
Locus tag J5285_RS01560 Protein ID WP_027676616.1
Coordinates 338028..338294 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A4D7DS53
Locus tag J5285_RS01565 Protein ID WP_027676615.1
Coordinates 338373..338624 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5285_RS01545 (J5285_01545) 333036..334988 + 1953 WP_027676619.1 methyl-accepting chemotaxis protein -
J5285_RS01550 (J5285_01550) 335175..336317 + 1143 WP_027676618.1 alpha-hydroxy acid oxidase -
J5285_RS01555 (J5285_01555) 336748..338016 + 1269 WP_027676617.1 D-alanyl-D-alanine carboxypeptidase -
J5285_RS01560 (J5285_01560) 338028..338294 - 267 WP_027676616.1 Txe/YoeB family addiction module toxin Toxin
J5285_RS01565 (J5285_01565) 338373..338624 - 252 WP_027676615.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J5285_RS01570 (J5285_01570) 338682..339422 - 741 WP_027676614.1 metallophosphoesterase family protein -
J5285_RS01575 (J5285_01575) 339428..339784 - 357 WP_027676613.1 hydroxyisourate hydrolase -
J5285_RS01580 (J5285_01580) 339781..340281 - 501 WP_027676612.1 ureidoglycolate lyase -
J5285_RS01585 (J5285_01585) 340298..340660 - 363 WP_027676611.1 DUF86 domain-containing protein -
J5285_RS01590 (J5285_01590) 340657..340950 - 294 WP_027676610.1 nucleotidyltransferase family protein -
J5285_RS01595 (J5285_01595) 341012..341515 - 504 WP_027676609.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
J5285_RS01600 (J5285_01600) 341512..342435 - 924 WP_027676608.1 allantoinase PuuE -
J5285_RS01605 (J5285_01605) 342514..343221 - 708 WP_027676607.1 DUF1045 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10639.28 Da        Isoelectric Point: 9.7753

>T197446 WP_027676616.1 NZ_CP072167:c338294-338028 [Agrobacterium larrymoorei]
ILLSWTSKGWEDYLYWQQADKKVLVRINELIRDALRHPFEGIGKPEPLRFNLKGLWSRRITQEHRLIYAIRDEGDGRTLV
VLQCRYHY

Download         Length: 267 bp

>T197446 NZ_CP096187:c290329-290042 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACACTCAAACACGCCGGGGATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9491.73 Da        Isoelectric Point: 4.3516

>AT197446 WP_027676615.1 NZ_CP072167:c338624-338373 [Agrobacterium larrymoorei]
MRTVMFSTARSELSTLLDQVSHDRVAVEIVRRDKPSAILIDKNEYEGLMETLHLYSSPANIGRLMEAMDEMDKGDYQQSD
LID

Download         Length: 252 bp

>AT197446 NZ_CP096187:c290638-290336 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D7DXW7

Antitoxin

Source ID Structure
AlphaFold DB A0A4D7DS53

References