Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 328212..328797 Replicon chromosome
Accession NZ_CP072167
Organism Agrobacterium larrymoorei strain AF3.44

Toxin (Protein)


Gene name PumA Uniprot ID A0A4D7DTW6
Locus tag J5285_RS01515 Protein ID WP_027676625.1
Coordinates 328212..328499 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J5285_RS01520 Protein ID WP_027676624.1
Coordinates 328501..328797 (+) Length 99 a.a.

Genomic Context

J5285_RS01500J5285_RS01505J5285_RS01510J5285_RS01515J5285_RS01520J5285_RS01530J5285_RS01535J5285_RS01540J5285_RS01525
Location: 323335..324801 (1467 bp)
Type: Others
Protein ID: WP_027676628.1
Location: 324988..327327 (2340 bp)
Type: Others
Protein ID: WP_027676627.1
Location: 327337..328164 (828 bp)
Type: Others
Protein ID: WP_027676626.1
Location: 328212..328499 (288 bp)
Type: Toxin
Protein ID: WP_027676625.1
Location: 328501..328797 (297 bp)
Type: Antitoxin
Protein ID: WP_027676624.1
Location: 329147..330040 (894 bp)
Type: Others
Protein ID: WP_027676622.1
Location: 330155..331402 (1248 bp)
Type: Others
Protein ID: WP_027676621.1
Location: 331399..332706 (1308 bp)
Type: Others
Protein ID: WP_027676620.1
Location: 328812..329042 (231 bp)
Type: Others
Protein ID: WP_027676623.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J5285_RS01500 (J5285_01500)323335..324801+1467WP_027676628.1xanthine dehydrogenase small subunit-
J5285_RS01505 (J5285_01505)324988..327327+2340WP_027676627.1xanthine dehydrogenase molybdopterin binding subunit-
J5285_RS01510 (J5285_01510)327337..328164+828WP_027676626.1xanthine dehydrogenase accessory protein XdhC-
J5285_RS01515 (J5285_01515)328212..328499+288WP_027676625.1type II toxin-antitoxin system RelE/ParE family toxinToxin
J5285_RS01520 (J5285_01520)328501..328797+297WP_027676624.1putative addiction module antidote proteinAntitoxin
J5285_RS01525 (J5285_01525)328812..329042-231WP_027676623.1hypothetical protein-
J5285_RS01530 (J5285_01530)329147..330040+894WP_027676622.1transcriptional regulator GcvA-
J5285_RS01535 (J5285_01535)330155..331402+1248WP_027676621.1urate hydroxylase PuuD-
J5285_RS01540 (J5285_01540)331399..332706+1308WP_027676620.1guanine deaminase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-89)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11008.78 Da        Isoelectric Point: 10.5155

>T197445 WP_027676625.1 NZ_CP072167:328212-328499 [Agrobacterium larrymoorei]
MIRIRKTNIFSDWFTSLRDKRAQARIQVRIDRLSLGLLGDVKFFDGIGEMRIDYGPGYRVYFTRRQNEIVILLCGGDKGS
QTRDIERAIKIAAEV

Download         Length: 288 bp

>T197445 NZ_CP096187:c85237-84896 [Enterobacter roggenkampii]
ATGAAATCTCAACCTGCAACAACTTCGCGGGCGGTAAAGCCCTGCCTGTCACCCGTGGCAGTCTGGCAAATGCTGCTGAC
CCGACTGCTCGAAAAACACTATGGCCTGACGCTAAACGACACCCCGTTCAGTGATGAAACCGTAATTCAGGAACACATCA
ATGCCGGTATCACAATGGCTGATGCCGTGAATTTTCTGGTGGAGAAATACGAACTGGTCCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCCCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGCAACTGGTTTGTTGCGGCAAAG
CCGTAACAACGTAATGGGGTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10458.02 Da        Isoelectric Point: 4.8146

>AT197445 WP_027676624.1 NZ_CP072167:328501-328797 [Agrobacterium larrymoorei]
MKVEVTDWDTSDYLNGNEAVIAYLEASFEDGDPKVIAMALGNIAKAKGMSQVAKQAGITREALYKSLSEKGDPKLSTLIG
VMKALGLRLSVAPEERAA

Download         Length: 297 bp

>AT197445 NZ_CP096187:c85575-85258 [Enterobacter roggenkampii]
ATGTGTAACATCACATGGGGCCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTACAGGAGGGGAACCGGCT
GCATTATTTAGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACGCCGGATGCCGGAAGCTGGATGACACATTCCCGC
ACTTTATCAGCCAGATGGAATCCATGCTGACCATGGGCGAACTGAATCCGCAACACGCCCACTGCGTCACCCTGTATCAC
AACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCACCGTTTACCCCACTCCGCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4D7DTW6

Antitoxin

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Source
ID
Structure
No matching records found

References