Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 158489..159054 Replicon chromosome
Accession NZ_CP072167
Organism Agrobacterium larrymoorei strain AF3.44

Toxin (Protein)


Gene name parE Uniprot ID A0A4D7DZI7
Locus tag J5285_RS00695 Protein ID WP_027674231.1
Coordinates 158489..158782 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4D7DSM4
Locus tag J5285_RS00700 Protein ID WP_027674230.1
Coordinates 158770..159054 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5285_RS00680 (J5285_00680) 153847..155703 - 1857 WP_027674234.1 ABC transporter ATP-binding protein -
J5285_RS00685 (J5285_00685) 156118..156579 + 462 WP_027674233.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
J5285_RS00690 (J5285_00690) 156811..158463 + 1653 WP_027674232.1 Na/Pi cotransporter family protein -
J5285_RS00695 (J5285_00695) 158489..158782 - 294 WP_027674231.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J5285_RS00700 (J5285_00700) 158770..159054 - 285 WP_027674230.1 ribbon-helix-helix protein, CopG family Antitoxin
J5285_RS00705 (J5285_00705) 159132..159407 - 276 WP_027674229.1 hypothetical protein -
J5285_RS00710 (J5285_00710) 159533..160444 + 912 WP_027674228.1 oxygen-dependent coproporphyrinogen oxidase -
J5285_RS00715 (J5285_00715) 160611..160877 + 267 WP_027674227.1 hypothetical protein -
J5285_RS00720 (J5285_00720) 161029..161217 + 189 WP_027674226.1 DUF1059 domain-containing protein -
J5285_RS00725 (J5285_00725) 161447..162694 - 1248 WP_027674225.1 CCA tRNA nucleotidyltransferase -
J5285_RS00730 (J5285_00730) 162691..163338 - 648 WP_027674224.1 CoA pyrophosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-44)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11037.89 Da        Isoelectric Point: 9.5450

>T197444 WP_027674231.1 NZ_CP072167:c158782-158489 [Agrobacterium larrymoorei]
MPQLIWTPEALRDVQRCYRFLAPKNPDAASRAIKSIREKMRMIVTHPAIGRPVDKMAPEFRELLIPFGESGYVALYRLDG
DLAVVLAVRHQNEAGYT

Download         Length: 294 bp

>T197444 NZ_CP096184:289942-290307 [Demequina sp. TMPB413]
ATGAGGCGCGGCGAGATCAGGTGGGTAGCGCTCGATGCCGGCGCCGACGCGGAGGCACGTTCGCGCGCTCAGCGCCCCGC
GGTGATCGTCTCTAACGACGGCGCCAACACGGCGGCCGCACGGCGCGGTTCTGGAGCTGTCACTGTGGTGCCCTTGACCA
CGTCCGACGCGCCCGCGAAGCCCTTCCAGGTAGCACTGGCCGCCGGCGTCGGCGGTCTGCCCAGGGCAGCCAAAGCCATG
GCCGAGCAAGTGCGCACCGTCTCTGCGGGACGCGTCGGCCCGAGCATCGGCATGCTGTCGCTGAGCGACGTAGCCAAGAT
CGATGACGCCTTGCGGCTACACCTCGGCCTCGATCGCGGGCGTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10729.96 Da        Isoelectric Point: 6.2152

>AT197444 WP_027674230.1 NZ_CP072167:c159054-158770 [Agrobacterium larrymoorei]
MPGPHPVAVKLDPEVHARMRKLAQAQHRSTHYLMREAIAQYVEREEKRAAFRQDALEAWSAYQASGSHLNQTEADEWLAK
LEAGQDVEPPECHN

Download         Length: 285 bp

>AT197444 NZ_CP096184:289739-289942 [Demequina sp. TMPB413]
GTGAAGCTCAGCATCAGCTTGACCGACGATGACGTCGCCTTGATCGATCAGTTCGCGGCCGCAGGTGACTACCCTTCCCG
CTCCGCAGTCATTCAGCACGCGCTCGCCAGGCTCCGCGCCCAGGGCCTCCACGGCGACTACGCCGACGCCTGGACGGAGT
TCTCGGATGGCGGCGACGCAGGCCGCTGGGAGGCGTCGTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D7DZI7

Antitoxin

Source ID Structure
AlphaFold DB A0A4D7DSM4

References