Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1422185..1423674 Replicon chromosome
Accession NZ_CP072163
Organism Rhizobium sp. B21/90

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag J5278_RS24565 Protein ID WP_209186796.1
Coordinates 1422412..1423674 (+) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag J5278_RS24560 Protein ID WP_209186795.1
Coordinates 1422185..1422415 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5278_RS24525 (J5278_24545) 1417488..1417736 - 249 WP_209186791.1 hypothetical protein -
J5278_RS24530 (J5278_24550) 1417767..1418114 - 348 WP_247749904.1 hypothetical protein -
J5278_RS24535 (J5278_24555) 1418403..1418891 - 489 WP_209186792.1 nuclear transport factor 2 family protein -
J5278_RS31230 1419288..1419507 + 220 Protein_1265 IS66 family transposase -
J5278_RS24545 (J5278_24565) 1419533..1419760 - 228 WP_209186807.1 DUF6429 family protein -
J5278_RS24550 (J5278_24570) 1419964..1421595 - 1632 WP_209186808.1 FAD-dependent oxidoreductase -
J5278_RS24555 (J5278_24575) 1421763..1422008 - 246 WP_209186794.1 hypothetical protein -
J5278_RS24560 (J5278_24580) 1422185..1422415 + 231 WP_209186795.1 helix-turn-helix transcriptional regulator Antitoxin
J5278_RS24565 (J5278_24585) 1422412..1423674 + 1263 WP_209186796.1 type II toxin-antitoxin system HipA family toxin Toxin
J5278_RS31235 1424410..1424466 + 57 WP_257623477.1 hypothetical protein -
J5278_RS24575 (J5278_24595) 1424958..1425767 - 810 WP_209186797.1 mechanosensitive ion channel -
J5278_RS24580 (J5278_24600) 1425998..1426768 - 771 WP_209186798.1 SDR family NAD(P)-dependent oxidoreductase -
J5278_RS24585 (J5278_24605) 1427373..1427801 + 429 WP_209187847.1 MucR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(151-381)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45307.99 Da        Isoelectric Point: 5.7044

>T197443 WP_209186796.1 NZ_CP072163:1422412-1423674 [Rhizobium sp. B21/90]
MTVRVLNVWWNGRIVGQFTQDQHGDIGFAYAEAWLEDEKALPLSVSLPKRPERFSRRECRPFFGGLLPEESQRLVAAQAL
GVSPANDFALLDRLGGDVAGALQLLPEDQEPIGGGLIADRQTAALDEVGIVRILDALPTRPLLAGQEGLRLSLAGAQSKA
PVVLIDGQVALPLPGQATTHILKPPIARFPGTTENEAFAMRLAAAIGLDVAPVDPRSANGRPFLLVNRYDRHHDGDGVVL
RIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRRVSARPGTDIAKLLDAAIFNLVIGNADAHGKNFSILYDHSGPRMA
PLYDLLSTVAYPDLSPKLAMRIGKRATLADMDADGWQAFSKETGVSLPLVRRRVKELTDATGDAIPRLLEDMSPLAADPV
SLNRVAALIADRAKLVALSI

Download         Length: 1263 bp

>T197443 NZ_CP096170:c14266-13916 [Shewanella sp. JNE2]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8069.42 Da        Isoelectric Point: 10.5998

>AT197443 WP_209186795.1 NZ_CP072163:1422185-1422415 [Rhizobium sp. B21/90]
MAKQVSSPAEIGALIRSTRKAQNLRQDELAGVSGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSIDILAPGERRK

Download         Length: 231 bp

>AT197443 NZ_CP096170:c13911-13609 [Shewanella sp. JNE2]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References