Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 585683..586347 Replicon chromosome
Accession NZ_CP072163
Organism Rhizobium sp. B21/90

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5278_RS20865 Protein ID WP_209186127.1
Coordinates 585683..586111 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5278_RS20870 Protein ID WP_209186126.1
Coordinates 586108..586347 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5278_RS20845 (J5278_20860) 580749..582302 - 1554 WP_111221723.1 IS21 family transposase -
J5278_RS20850 (J5278_20865) 582436..583530 - 1095 WP_257623488.1 group II intron reverse transcriptase/maturase -
J5278_RS20855 (J5278_20870) 584300..584976 - 677 Protein_521 IS3 family transposase -
J5278_RS20860 (J5278_20875) 585321..585611 - 291 WP_219258988.1 hypothetical protein -
J5278_RS20865 (J5278_20880) 585683..586111 - 429 WP_209186127.1 type II toxin-antitoxin system VapC family toxin Toxin
J5278_RS20870 (J5278_20885) 586108..586347 - 240 WP_209186126.1 Arc family DNA-binding protein Antitoxin
J5278_RS20875 (J5278_20890) 586603..587317 - 715 Protein_525 IS6 family transposase -
J5278_RS20880 (J5278_20895) 587357..587605 - 249 WP_142831608.1 hypothetical protein -
J5278_RS20885 (J5278_20900) 587955..588299 + 345 WP_209207006.1 hypothetical protein -
J5278_RS20890 (J5278_20905) 589360..589764 - 405 WP_209187025.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 570105..599265 29160
- inside IScluster/Tn - - 577096..587317 10221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15224.51 Da        Isoelectric Point: 5.8927

>T197442 WP_209186127.1 NZ_CP072163:c586111-585683 [Rhizobium sp. B21/90]
MILLDTNVISEPLKSQPDPRVAAWIDTQAVETLYVAAISLAELRYGIAVHPDGKKKQAVQEKLDRLMLPLFRGRIMPFDE
AAAQAYAELRAAAAKKGKAIGDSDGYIAATAKANGLMIATRDTSPFEAAGLTVINPWEASNG

Download         Length: 429 bp

>T197442 NZ_CP096169:c4427839-4427309 [Shewanella sp. JNE2]
GTGAGTTATTCCAAAATTTTCAAAGAATTGGATAAATCACTACACGATAGAGCATCATTTGACTGTGGCGAAGCAGAGTT
AAACGATTTTATCCAAACTCAAGCAGCAAAACATATGCAAGCAGGTATTAGCCGTACAATGGTTTTACCTGCTGCTATGC
CATTGCCCAATCAAAAATATCCAATTTGCTCATTTTATACTATCGCACCAAGTTCAATTTGCCGTGATACCTTGCCGCAA
GCTATTGGCAAAAAGTTACCACGCTATCCCATTCCGGTCTTTCTGCTTGCTCAACTTGCGGTTCATAAAGAGTTTCATGG
CAGTGGGTTAGGTAAAGCTAGCTTAATTAAAGCACTAGAATATCTGTGGGAAATTAACGCTCACATGAGAGCTTATGCCA
TTGTTGTCGATTGCTTAACTGACCAAGCTGAATCATTCTACGCAAAATATGGTTTCGAGGTTCTTTGTGAAATCAACGGT
CGTGTCAGAATGTTTATTCCAATGAAAACGGTCGGTCAGTTATTCACTTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8686.90 Da        Isoelectric Point: 7.2054

>AT197442 WP_209186126.1 NZ_CP072163:c586347-586108 [Rhizobium sp. B21/90]
MASITIRNVPDEVHRALRVRAAQHGRSAEAEIRIILEQAAKPEGRVKLGSLLTQIGQEVGGFDLTIERDRTPSPPVSFE

Download         Length: 240 bp

>AT197442 NZ_CP096169:c4428105-4427836 [Shewanella sp. JNE2]
ATGGCGACTGCAAGACTTGATATCCGTTTGGATGAAGAAATCAAAGCTAAGGCTGAGAAAGCATCCGCTTTGCTCGGGTT
AAAAAGCTTAACTGAATACGTTGTTCGCTTAATGGACGAAGATGCAACTCAGGTGATAGCTGAGCATGAAAGCGTTACGG
TTAAAGCAGATGTATTCGACCAATTCATAATGGCTTGTGATGAGGCTAAGGTTCCGAATAAGGCATTGCGTGAAGCGGCT
GCATTTACTAAAAATGGTGAGTTTAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References