Detailed information of TA system TA197417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 191097..192586
• Replicon: chromosome
• Accession: NZ_CP072152
• Organism: Rhizobium sp. K15/93

Toxin (Protein)

• Gene name: HipA1
• Uniprot ID: -
• Locus tag: J5280_RS19475
• Protein ID: WP_209186796.1
• Coordinates: 191097..192359 (-)
• Length: 421 a.a.

Antitoxin (Protein)

• Gene name: HipB1
• Uniprot ID: -
• Locus tag: J5280_RS19480
• Protein ID: WP_209186795.1
• Coordinates: 192356..192586 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5280_RS19455 (J5280_19450)	186970..187398	-	429	WP_209186809.1	MucR family transcriptional regulator	-
J5280_RS19460 (J5280_19455)	188003..188773	+	771	WP_209186798.1	SDR family NAD(P)-dependent oxidoreductase	-
J5280_RS19465 (J5280_19460)	189004..189813	+	810	WP_209186797.1	mechanosensitive ion channel	-
J5280_RS19470 (J5280_19465)	190208..190487	-	280	Protein_181	helix-turn-helix domain-containing protein	-
J5280_RS19475 (J5280_19470)	191097..192359	-	1263	WP_209186796.1	type II toxin-antitoxin system HipA family toxin	Toxin
J5280_RS19480 (J5280_19475)	192356..192586	-	231	WP_209186795.1	helix-turn-helix transcriptional regulator	Antitoxin
J5280_RS19485 (J5280_19480)	192763..193008	+	246	WP_209186794.1	hypothetical protein	-
J5280_RS19490 (J5280_19485)	193176..194807	+	1632	WP_209186808.1	FAD-dependent oxidoreductase	-
J5280_RS19495 (J5280_19490)	195011..195238	+	228	WP_209186807.1	DUF6429 family protein	-
J5280_RS31850	195264..195483	-	220	Protein_187	IS66 family transposase	-
J5280_RS19505 (J5280_19500)	195880..196368	+	489	WP_209186792.1	nuclear transport factor 2 family protein	-
J5280_RS19510 (J5280_19505)	196657..197004	+	348	WP_247749904.1	hypothetical protein	-
J5280_RS19515 (J5280_19510)	197035..197283	+	249	WP_209186791.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (151-381)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-69)

Sequences

Toxin

Protein

• Length: 421 a.a.
• Molecular weight: 45307.99 Da
• Isoelectric Point: 5.7044

>T197417 WP_209186796.1 NZ_CP072152:c192359-191097 [Rhizobium sp. K15/93]
MTVRVLNVWWNGRIVGQFTQDQHGDIGFAYAEAWLEDEKALPLSVSLPKRPERFSRRECRPFFGGLLPEESQRLVAAQAL
GVSPANDFALLDRLGGDVAGALQLLPEDQEPIGGGLIADRQTAALDEVGIVRILDALPTRPLLAGQEGLRLSLAGAQSKA
PVVLIDGQVALPLPGQATTHILKPPIARFPGTTENEAFAMRLAAAIGLDVAPVDPRSANGRPFLLVNRYDRHHDGDGVVL
RIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRRVSARPGTDIAKLLDAAIFNLVIGNADAHGKNFSILYDHSGPRMA
PLYDLLSTVAYPDLSPKLAMRIGKRATLADMDADGWQAFSKETGVSLPLVRRRVKELTDATGDAIPRLLEDMSPLAADPV
SLNRVAALIADRAKLVALSI

Nucleotide

• Length: 1263 bp

>T197417 NZ_CP096163:4198324-4198578 [Shewanella sp. JNE10-2]
ATGAACAAAAAACATTTAAGAACGTTGACGGCTATCTTTGCTAGGCCTGTCAGCGGAGCTATCAAGTGGTCTGATATTGA
AGCGCTGTTTATTGCTCTAGGGGCTGACATTGAAGAGCGTGAGGGGTCTCGAATTGGTGTGGTGCTGTTTGGTGAAGTTC
AGGTATATCACCGCCCACATCCTCAGAAAGAAACTGACAAAGACGCAGTGATAAACATCAAAAAATGGTTAGAAAGGAAC
GGGGTGAAAGCATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8069.42 Da
• Isoelectric Point: 10.5998

>AT197417 WP_209186795.1 NZ_CP072152:c192586-192356 [Rhizobium sp. K15/93]
MAKQVSSPAEIGALIRSTRKAQNLRQDELAGVSGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSIDILAPGERRK

Nucleotide

• Length: 231 bp

>AT197417 NZ_CP096163:4198575-4198916 [Shewanella sp. JNE10-2]
ATGAAAAATCTTATGATGATCAACGGGGTAAAAGCCTTTATTGATTATGATCCAGACGCTGAAACATTCCGTGGTGAGTT
CGTAGGCTTAAACGGCGGCGCGGATTTCTATGGTGAAAGCGTCGCTCAATTGGAAGCCGAGGGCGCGAAGTCATTAAGCG
TTTTTTTAGAGATGTGTCAGGAGCGTGGCATTGAGCCTTACAAAAACTTCTCTGGCAAATTCAACGTTCGGATCTCGCCA
GAGGTTCACGCTCGACTTAATGAAATTGCGCTATCGCAAAGCATTAGTTTGAATGCAGCGGTAGAAAATGCAGTCAATGA
CTACATTGCACATTCAGCGTAG