Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1565400..1566064 Replicon chromosome
Accession NZ_CP072147
Organism Rhizobium sp. K1/93

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5287_RS25795 Protein ID WP_209186127.1
Coordinates 1565400..1565828 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5287_RS25800 Protein ID WP_209186126.1
Coordinates 1565825..1566064 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5287_RS25770 (J5287_25755) 1561204..1562031 + 828 WP_209186131.1 aldo/keto reductase -
J5287_RS25775 (J5287_25760) 1562254..1562682 + 429 WP_209186130.1 hypothetical protein -
J5287_RS25780 (J5287_25765) 1563062..1563736 + 675 WP_224128900.1 permease -
J5287_RS25785 (J5287_25770) 1564076..1564579 + 504 WP_247749418.1 alpha/beta hydrolase -
J5287_RS32010 1564512..1564769 + 258 WP_257625630.1 alpha/beta hydrolase -
J5287_RS25790 (J5287_25775) 1565038..1565328 - 291 WP_209186128.1 hypothetical protein -
J5287_RS25795 (J5287_25780) 1565400..1565828 - 429 WP_209186127.1 type II toxin-antitoxin system VapC family toxin Toxin
J5287_RS25800 (J5287_25785) 1565825..1566064 - 240 WP_209186126.1 Arc family DNA-binding protein Antitoxin
J5287_RS25805 (J5287_25790) 1566320..1566704 - 385 Protein_1450 DDE-type integrase/transposase/recombinase -
J5287_RS25810 (J5287_25795) 1566714..1568312 - 1599 WP_209187040.1 IS66 family transposase -
J5287_RS25815 (J5287_25800) 1568386..1568730 - 345 WP_209187038.1 IS66 family insertion sequence element accessory protein TnpB -
J5287_RS25820 (J5287_25805) 1568727..1569110 - 384 WP_209187039.1 transposase -
J5287_RS25825 (J5287_25810) 1569180..1569524 - 345 Protein_1454 IS6 family transposase -
J5287_RS25830 (J5287_25815) 1569564..1569812 - 249 WP_142831608.1 hypothetical protein -
J5287_RS25835 (J5287_25820) 1569809..1570078 - 270 WP_209187024.1 hypothetical protein -
J5287_RS25840 (J5287_25825) 1570162..1570506 + 345 WP_142831609.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15224.51 Da        Isoelectric Point: 5.8927

>T197409 WP_209186127.1 NZ_CP072147:c1565828-1565400 [Rhizobium sp. K1/93]
MILLDTNVISEPLKSQPDPRVAAWIDTQAVETLYVAAISLAELRYGIAVHPDGKKKQAVQEKLDRLMLPLFRGRIMPFDE
AAAQAYAELRAAAAKKGKAIGDSDGYIAATAKANGLMIATRDTSPFEAAGLTVINPWEASNG

Download         Length: 429 bp

>T197409 NZ_CP096143:2334919-2335053 [Xanthomonas prunicola]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTCGGTATGCTGTCGGGCTGCAACACCGTCGCAGGTGC
TGGCAAGGACGTGAAGGGTGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8686.90 Da        Isoelectric Point: 7.2054

>AT197409 WP_209186126.1 NZ_CP072147:c1566064-1565825 [Rhizobium sp. K1/93]
MASITIRNVPDEVHRALRVRAAQHGRSAEAEIRIILEQAAKPEGRVKLGSLLTQIGQEVGGFDLTIERDRTPSPPVSFE

Download         Length: 240 bp

>AT197409 NZ_CP096143:2334692-2334844 [Xanthomonas prunicola]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACATGCAGGGCGCAGGTGGGAAGGTCGAGAAAACCGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References