Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 224160..224824 Replicon plasmid unnamed1
Accession NZ_CP072143
Organism Rhizobium sp. L51/94

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5274_RS25170 Protein ID WP_209186127.1
Coordinates 224396..224824 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5274_RS25165 Protein ID WP_209186126.1
Coordinates 224160..224399 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5274_RS25150 (J5274_25155) 220816..221061 - 246 WP_142832030.1 hypothetical protein -
J5274_RS29145 222222..222619 - 398 Protein_205 integrase -
J5274_RS25160 (J5274_25165) 223142..223810 - 669 WP_219275717.1 HAD family phosphatase -
J5274_RS25165 (J5274_25170) 224160..224399 + 240 WP_209186126.1 Arc family DNA-binding protein Antitoxin
J5274_RS25170 (J5274_25175) 224396..224824 + 429 WP_209186127.1 type II toxin-antitoxin system VapC family toxin Toxin
J5274_RS25175 (J5274_25180) 224896..225288 + 393 WP_219275718.1 hypothetical protein -
J5274_RS25180 (J5274_25185) 225271..226350 - 1080 WP_111223089.1 IS630 family transposase -
J5274_RS25185 (J5274_25190) 226503..226688 + 186 WP_219275719.1 hypothetical protein -
J5274_RS25190 (J5274_25195) 226754..226999 + 246 WP_219275720.1 hypothetical protein -
J5274_RS25195 (J5274_25200) 227145..227899 - 755 Protein_213 SDR family oxidoreductase -
J5274_RS25200 (J5274_25205) 228275..228901 + 627 WP_219275721.1 recombinase family protein -
J5274_RS25205 (J5274_25210) 228908..229366 + 459 Protein_215 DUF4158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..364788 364788
- flank IS/Tn - - 225271..226350 1079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15224.51 Da        Isoelectric Point: 5.8927

>T197397 WP_209186127.1 NZ_CP072143:224396-224824 [Rhizobium sp. L51/94]
MILLDTNVISEPLKSQPDPRVAAWIDTQAVETLYVAAISLAELRYGIAVHPDGKKKQAVQEKLDRLMLPLFRGRIMPFDE
AAAQAYAELRAAAAKKGKAIGDSDGYIAATAKANGLMIATRDTSPFEAAGLTVINPWEASNG

Download         Length: 429 bp

>T197397 NZ_CP096130:57053-57397 [Leptospira interrogans]
TTGGTAAAGTATAGAAACTATACTCCTGAAAAAGGAGATATAGTGTGGCTGAACTTTACTCCTCAAGCAGGTCATGAACA
GAAAGGTCGTAGACCTGCACTTGTTTTATCGCCTAAGGAATATAATTCAAAGACAGGGTTAGCAATATTTTGTCCAATTA
CCAGTAAAATTAAAGGTTATCCATTCGAAGTGTTGATTAAATCAAAAAAAATCGATGGTGTAATTCTTTCTGATCAAGTA
AAAAACTTAGATTGGACTATCCGTGAAGCAGAATTTATTGAATCAATAAATAAAGTTTCTTTAAAAGAAGTTTTAGATAA
TATTAAATTATTAATATTAACCTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8686.90 Da        Isoelectric Point: 7.2054

>AT197397 WP_209186126.1 NZ_CP072143:224160-224399 [Rhizobium sp. L51/94]
MASITIRNVPDEVHRALRVRAAQHGRSAEAEIRIILEQAAKPEGRVKLGSLLTQIGQEVGGFDLTIERDRTPSPPVSFE

Download         Length: 240 bp

>AT197397 NZ_CP096130:56823-57059 [Leptospira interrogans]
ATGGAATCAATTATTCAAAAATGGGGTAATAGCTTAGGAATTAGAATTCCAAAAGCAATGGCAACGGAATTAGAGTTAAA
TGATGGAAGCCATGTTGAATTACAATATGAAGGAGATAAGATTGTAATATATCCAATGAAAAAAGCTTCATTGGAAGATA
AACTTTCTAAAATTACGAAACAAAATCTTCACTCTGAAATATCTACTGGTAATTCTATAGGCAATGAAGCTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References