Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1126611..1127191 Replicon chromosome
Accession NZ_CP072142
Organism Rhizobium sp. L51/94

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5274_RS23130 Protein ID WP_219275265.1
Coordinates 1126611..1126994 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5274_RS23135 Protein ID WP_142831764.1
Coordinates 1126991..1127191 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5274_RS23105 (J5274_23110) 1122070..1122654 - 585 WP_219271068.1 plasmid pRiA4b ORF-3 family protein -
J5274_RS23110 (J5274_23115) 1122654..1124312 - 1659 WP_142832615.1 IS66 family transposase -
J5274_RS23115 (J5274_23120) 1124390..1124737 - 348 WP_046119556.1 IS66 family insertion sequence element accessory protein TnpB -
J5274_RS23120 (J5274_23125) 1124734..1125081 - 348 WP_111217014.1 transposase -
J5274_RS23125 (J5274_23130) 1125576..1126151 - 576 WP_257625694.1 alpha/beta hydrolase -
J5274_RS23130 (J5274_23135) 1126611..1126994 - 384 WP_219275265.1 type II toxin-antitoxin system VapC family toxin Toxin
J5274_RS23135 (J5274_23140) 1126991..1127191 - 201 WP_142831764.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J5274_RS23140 (J5274_23145) 1127353..1128549 - 1197 WP_219275266.1 ROK family transcriptional regulator -
J5274_RS23145 (J5274_23150) 1128781..1130019 + 1239 WP_219275267.1 extracellular solute-binding protein -
J5274_RS23150 (J5274_23155) 1130081..1130980 + 900 WP_219275268.1 sugar ABC transporter permease -
J5274_RS23155 (J5274_23160) 1130977..1131843 + 867 WP_219275269.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1124390..1124737 347


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14065.28 Da        Isoelectric Point: 7.4753

>T197395 WP_219275265.1 NZ_CP072142:c1126994-1126611 [Rhizobium sp. L51/94]
VILVDTSIWIDHFRHSDADLRKVIADDRLLCHPVVIGELALGSLRDRGVVMAFFSAQREALVASHDEVMKMIDRHSIFSM
GIGYTDAHLLASTLLDRRSLLWTRDKRLAAAAQKAGASLYAPTIAPN

Download         Length: 384 bp

>T197395 NZ_CP096129:1023543-1023884 [Leptospira interrogans]
ATGATTCGTGGTGAAATTTGGTGGGTAGATTTGGGAATTCCATTTGGAAGTGAGCCTGGATTTAAACGTCCAGTTCTTAT
AATTCAAGATGACTCTTTTAATCAAAGTAATATTAATACAATAGTTTCGATTGCAATTACATCGAATTTAAATCTATCTG
AAGCACCAGGTAATGTTTTCATTAGTAAAAAAGATTCGAGTTTATCAAAGGACTCGGTCATAAATGTCTCTCAAATTGTG
ACTTTAGATAAAGAAAGATTTCTTAACAAAGCGGGTAAACTTAAATCAAATAAATTAGGTGAAGTTGAAATTGGGCTTAA
GTTGGTTACAGGCTTAGATTGA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7125.13 Da        Isoelectric Point: 10.4525

>AT197395 WP_142831764.1 NZ_CP072142:c1127191-1126991 [Rhizobium sp. L51/94]
MRSTINLDDNLMEQARSLTGTKETAALVRQALETLVRVESGKRLAALGGTMPDAEAAPRRRSEAAK

Download         Length: 201 bp

>AT197395 NZ_CP096129:1023308-1023556 [Leptospira interrogans]
ATGAAGACGGCGATTTCAATTCCTGATGAGTTATTTAGGGCTGCCGAGAAAATAGCTAAAAAACTTGGGATTCCTCGAAG
CCAGTTATTTGCAAAAGCATTAGAAGAATTTATCCAATCTCATAGTAAAGAATCTGTAACTGAGAAATTAAATAAAATCT
ACAGTAATAAATCCAAAGAAACTAGAAATAATATTACTGACTTATCCGTAGAATCGCTTCGTAAGAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References