Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 91545..93034 Replicon chromosome
Accession NZ_CP072142
Organism Rhizobium sp. L51/94

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag J5274_RS18495 Protein ID WP_219275441.1
Coordinates 91545..92807 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag J5274_RS18500 Protein ID WP_209187840.1
Coordinates 92804..93034 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5274_RS18475 (J5274_18480) 87423..87851 - 429 WP_219275648.1 MucR family transcriptional regulator -
J5274_RS18480 (J5274_18485) 88451..89221 + 771 WP_219275438.1 SDR family NAD(P)-dependent oxidoreductase -
J5274_RS18485 (J5274_18490) 89451..90260 + 810 WP_219275439.1 mechanosensitive ion channel -
J5274_RS18490 (J5274_18495) 90656..90934 - 279 WP_219275440.1 helix-turn-helix transcriptional regulator -
J5274_RS18495 (J5274_18500) 91545..92807 - 1263 WP_219275441.1 type II toxin-antitoxin system HipA family toxin Toxin
J5274_RS18500 (J5274_18505) 92804..93034 - 231 WP_209187840.1 helix-turn-helix transcriptional regulator Antitoxin
J5274_RS18505 (J5274_18510) 93625..95256 + 1632 WP_219275649.1 FAD-dependent oxidoreductase -
J5274_RS18510 (J5274_18515) 95460..95690 + 231 WP_142832068.1 DUF6429 family protein -
J5274_RS18515 (J5274_18520) 96243..96554 - 312 WP_219275442.1 hypothetical protein -
J5274_RS18520 (J5274_18525) 96930..97310 + 381 WP_219275443.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45254.95 Da        Isoelectric Point: 5.4652

>T197393 WP_219275441.1 NZ_CP072142:c92807-91545 [Rhizobium sp. L51/94]
MTVRVLNVWWNGRIVGQFTQDRHGDIGFAYAEAWLEDEKALPLSVSLPKRPERFSSQECRPFFGGLLPEESQRLVAAQAL
GVSPANDFALLDRLGGDVAGALQLLPEDHEPIGGGLIADRQTAALDEAGIVRILDALPTRPLLAGQEGLRLSLAGAQSKA
PVVLIDGQVALPLPGQATTHILKPPIARFPGTTENEAFAMMLAAAIGLDVAPVDPRSANGRPFLLVNRYDRHHDGDGVVL
RIHQEDFCQALGVPPETKYASEGGPTFKDCFELLRRVSARPGTDIVKLLDATIFNLVIGNADAHGKNFAILYDHSGPRMA
PLYDLLSTVAYPDLSPKLAMRIGKRATLADMDADGWQAFSKETGVSLPLVRRRVKELTDATGDAIPRLLEDMSPLAADPV
SLNRVAALIADRAKLVALSM

Download         Length: 1263 bp

>T197393 NZ_CP096122:c24992-24702 [Acinetobacter portensis]
ATGCGGACGATTAAGTACACATCAGCATTCAAGAAAGACTATAAACGTGAGAAAAAAGGGCAGCATCGAAATACAGTAGA
TGCTGAACTACAAACTGTTTTAGAGTTATTGCAAGCTGATGAAGCCTTGCCTGAAAAGTATCGTGACCATGCTTTGGTCA
GTAATTGGGTAGGTCATCGTGACTGCCATATCAAACCAGATCTTGTTTTGATCTATAAAAAAACAGAGGAAGGCGAACTA
CTAATTTTGAAATTAGTTAGGTTAGGTAGTCATAGTGAATTGGAAATTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8099.41 Da        Isoelectric Point: 10.1937

>AT197393 WP_209187840.1 NZ_CP072142:c93034-92804 [Rhizobium sp. L51/94]
MAKQVSSPAEIGALVRSTRKAQNLRQDELAGVSGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSIDILDPGERRK

Download         Length: 231 bp

>AT197393 NZ_CP096122:c25239-24979 [Acinetobacter portensis]
ATGGCTTCAAATGCACTAGTAACTACTCGCATTAACGAAAACATTAAGCATGAAGCAACTGAAGTTCTTGCAACAATGGG
CTTAACTGTCTCAGATGCAGTTCGCTTGTTGTTAACCAAGGTAGCGAAAGAAAAGGCTCTGCCTTTTGAAATTTGGCAGC
CCAGTGCTGAAACCATTGCTGCAATGGAAGAAGATCTAAGCAAAGCAAAGAGCTTCACTTCTGTAAAAGATTTGATGGCT
GATCTAAATGCGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References