Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3208846..3209442 Replicon chromosome
Accession NZ_CP072141
Organism Rhizobium sp. L51/94

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag J5274_RS15660 Protein ID WP_142823292.1
Coordinates 3209149..3209442 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag J5274_RS15655 Protein ID WP_142823291.1
Coordinates 3208846..3209148 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5274_RS15635 (J5274_15635) 3205931..3206266 + 336 WP_142823289.1 BrnA antitoxin family protein -
J5274_RS15640 (J5274_15640) 3206511..3206687 + 177 WP_153816481.1 hypothetical protein -
J5274_RS15645 (J5274_15645) 3206863..3207315 - 453 WP_142823290.1 GatB/YqeY domain-containing protein -
J5274_RS15650 (J5274_15650) 3207601..3208806 + 1206 WP_142823609.1 glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit -
J5274_RS15655 (J5274_15655) 3208846..3209148 - 303 WP_142823291.1 putative addiction module antidote protein Antitoxin
J5274_RS15660 (J5274_15660) 3209149..3209442 - 294 WP_142823292.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J5274_RS15665 (J5274_15665) 3209525..3210931 - 1407 WP_142823293.1 MATE family efflux transporter -
J5274_RS15670 (J5274_15670) 3211078..3212316 - 1239 WP_142829287.1 TCR/Tet family MFS transporter -
J5274_RS15675 (J5274_15675) 3212487..3213398 - 912 WP_219274667.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lpsB/lpcC 3192188..3231422 39234


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-94)

Antitoxin

Uncharacterized protein HI1420

(8-97)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11253.10 Da        Isoelectric Point: 10.6024

>T197392 WP_142823292.1 NZ_CP072141:c3209442-3209149 [Rhizobium sp. L51/94]
MLEVRQTILFRRWFDGLKDKRAVERITQRIVRLQAGLFGDIKFFDGIGELRVDHGPGYRVYFVQRGSVLVILLWGGDKSS
QTRDIRKAKAMADDLEI

Download         Length: 294 bp

>T197392 NZ_CP096122:c23256-22963 [Acinetobacter portensis]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCTAAAGTCATAGAGCAGCCACATATTCCAAAGAACATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCAGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10452.03 Da        Isoelectric Point: 8.5285

>AT197392 WP_142823291.1 NZ_CP072141:c3209148-3208846 [Rhizobium sp. L51/94]
MPVKTLPFDAADHLQSGQSQLELLSDAFNSGSASYVAVALGVIARAKGMTEVSKTAGITREALYKALSADGDPKLSTLLG
VLNALDIQLKLAPRNKKAPD

Download         Length: 303 bp

>AT197392 NZ_CP096122:c23491-23246 [Acinetobacter portensis]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCCGTCAAAAAAGCTTTGCTTTCGGAAG
AAGATGAAGAATTATTAGCTCTTGTCCGTAAGCGCATTAACGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References