Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2739046..2740634 Replicon chromosome
Accession NZ_CP072130
Organism Klebsiella variicola strain F2R9

Toxin (Protein)


Gene name hipA Uniprot ID A0A1F2MCM0
Locus tag J5475_RS13315 Protein ID WP_008804919.1
Coordinates 2739046..2740368 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag J5475_RS13320 Protein ID WP_008804920.1
Coordinates 2740368..2740634 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5475_RS13300 (J5475_13300) 2734111..2736612 + 2502 WP_040968504.1 fimbria/pilus outer membrane usher protein -
J5475_RS13305 (J5475_13305) 2736600..2737604 + 1005 WP_008804917.1 fimbrial protein -
J5475_RS13310 (J5475_13310) 2737737..2739029 + 1293 WP_016161010.1 glycoside hydrolase family 10 protein -
J5475_RS13315 (J5475_13315) 2739046..2740368 - 1323 WP_008804919.1 type II toxin-antitoxin system HipA family toxin Toxin
J5475_RS13320 (J5475_13320) 2740368..2740634 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
J5475_RS13325 (J5475_13325) 2740900..2741226 - 327 WP_008804921.1 hydroxyisourate hydrolase -
J5475_RS13330 (J5475_13330) 2741223..2741723 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
J5475_RS13335 (J5475_13335) 2741701..2743080 - 1380 WP_032730340.1 nucleobase:cation symporter-2 family protein -
J5475_RS13340 (J5475_13340) 2743426..2744580 + 1155 WP_040968503.1 FAD-dependent urate hydroxylase HpxO -
J5475_RS13345 (J5475_13345) 2744561..2745484 - 924 WP_038422542.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48911.26 Da        Isoelectric Point: 7.9109

>T197375 WP_008804919.1 NZ_CP072130:c2740368-2739046 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T197375 NZ_CP096118:2569073-2569357 [Salmonella enterica subsp. enterica serovar Indiana]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTACGGGAACGACTCGAAAACCCTCGGGTTCCTGCTTCGCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGGCACAGAAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT197375 WP_008804920.1 NZ_CP072130:c2740634-2740368 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT197375 NZ_CP096118:2568835-2569083 [Salmonella enterica subsp. enterica serovar Indiana]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2MCM0

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References