Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1839133..1839723 Replicon chromosome
Accession NZ_CP072130
Organism Klebsiella variicola strain F2R9

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag J5475_RS08875 Protein ID WP_039104087.1
Coordinates 1839391..1839723 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag J5475_RS08870 Protein ID WP_039104089.1
Coordinates 1839133..1839390 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5475_RS08850 (J5475_08850) 1834743..1835318 + 576 WP_012541129.1 hypothetical protein -
J5475_RS08855 (J5475_08855) 1835497..1836333 + 837 WP_008804155.1 alpha/beta hydrolase -
J5475_RS08860 (J5475_08860) 1836540..1837511 + 972 WP_008804156.1 sensor domain-containing diguanylate cyclase -
J5475_RS08865 (J5475_08865) 1837508..1838605 - 1098 WP_040968706.1 AarF/UbiB family protein -
J5475_RS08870 (J5475_08870) 1839133..1839390 + 258 WP_039104089.1 antitoxin Antitoxin
J5475_RS08875 (J5475_08875) 1839391..1839723 + 333 WP_039104087.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J5475_RS08885 (J5475_08885) 1840046..1841482 + 1437 WP_016161429.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
J5475_RS08895 (J5475_08895) 1841855..1843309 - 1455 WP_008804170.1 AMP nucleosidase -
J5475_RS08900 (J5475_08900) 1843440..1843685 - 246 WP_008804171.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11895.77 Da        Isoelectric Point: 10.1839

>T197366 WP_039104087.1 NZ_CP072130:1839391-1839723 [Klebsiella variicola]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAIINEVLARLDAILS

Download         Length: 333 bp

>T197366 NZ_CP096114:c2121370-2121008 [Staphylococcus argenteus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTTGT
CATTATTCAAAATGACACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCCA
AAATACCGACCCATGTAGAGATTGAAAAGAAAAAATATAAACTGGATAAAGATTCAGTTATATTATTAGAACAAATTCGG
ACACTTGATAAAAAACGTTTAAAAGAAAAACTGACGTACTTATCAGACAACAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATACAATGGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9432.97 Da        Isoelectric Point: 4.4915

>AT197366 WP_039104089.1 NZ_CP072130:1839133-1839390 [Klebsiella variicola]
MYKTRLKKVGGSIMLAVPPAVLKALELSIDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT197366 NZ_CP096114:c2121537-2121367 [Staphylococcus argenteus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCAATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References