Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3366311..3366964 Replicon chromosome
Accession NZ_CP072122
Organism Acinetobacter baumannii strain KSK1

Toxin (Protein)


Gene name cptA Uniprot ID A0A246A3V9
Locus tag J5P21_RS16030 Protein ID WP_002054941.1
Coordinates 3366311..3366700 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag J5P21_RS16035 Protein ID WP_001288210.1
Coordinates 3366707..3366964 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5P21_RS16015 (J5P21_16015) 3361429..3363624 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
J5P21_RS16020 (J5P21_16020) 3363812..3364378 - 567 WP_000651536.1 rhombosortase -
J5P21_RS16025 (J5P21_16025) 3364456..3365541 - 1086 WP_000049106.1 hypothetical protein -
J5P21_RS16030 (J5P21_16030) 3366311..3366700 - 390 WP_002054941.1 hypothetical protein Toxin
J5P21_RS16035 (J5P21_16035) 3366707..3366964 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
J5P21_RS16040 (J5P21_16040) 3367152..3368324 + 1173 WP_001190546.1 acyl-CoA dehydrogenase family protein -
J5P21_RS16045 (J5P21_16045) 3368374..3369864 - 1491 WP_000415133.1 NAD(P)/FAD-dependent oxidoreductase -
J5P21_RS16050 (J5P21_16050) 3370046..3370423 - 378 WP_001216380.1 50S ribosomal protein L17 -
J5P21_RS16055 (J5P21_16055) 3370442..3371449 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15616.87 Da        Isoelectric Point: 10.2790

>T197358 WP_002054941.1 NZ_CP072122:c3366700-3366311 [Acinetobacter baumannii]
MINHLNFKLKYSHFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKVIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T197358 NZ_CP096040:c211112-210828 [Caulobacter segnis]
GTGGCGTATAGGCTCAGCCGGAAGGCCGAAGACGACATCATCCAGATCTATGTCTCGGGCGCGGAGATGTTCGGCCCCGA
GCAGGCCGAGCGCTACCATGAGGGCCTGGAACAGACCTTCGCCTTCCTGTCGGACTTTCCCTTCGCGGCGACGGAGCGCC
CCGAACTGCGAGGGGCGCGCGTCCATCCCTACAAGAGCCACATCATCGTCTACCGGCTCGACCGTGGGGATATCCTCGTC
CAGCGCGTCCGTCACGCCAGCGAAGACTGGGTCGGGCAACCCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT197358 WP_001288210.1 NZ_CP072122:c3366964-3366707 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT197358 NZ_CP096040:c211353-211102 [Caulobacter segnis]
ATGGCGACGATGAACGTGTCCCTGCCCGACGCCATGAAAGCGTGGGTCGAGGAACAGGCTGGAACGGGGCGCTACAGCAA
TGCCAGCGATTATGTGCGTGATCTGATCCGCCGGGACCAGGAACGCGCCGACAAGATCGCGGCGATGCAGCGCCTTATCG
AAGAGGCCGAGGAGAGCGGCGTCAGCCCCAGATCCATGAGCGAGGTCCTGGCGGCGGCGCGTCTCAAAGCCGCCGAACGC
CGTGGCGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246A3V9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References