Detailed information of TA system TA197357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2161151..2161830
• Replicon: chromosome
• Accession: NZ_CP072122
• Organism: Acinetobacter baumannii strain KSK1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: J5P21_RS10305
• Protein ID: WP_000838146.1
• Coordinates: 2161648..2161830 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: J5P21_RS10300
• Protein ID: WP_000966688.1
• Coordinates: 2161151..2161555 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5P21_RS10295 (J5P21_10295)	2160542..2161051	-	510	WP_000735548.1	hypothetical protein	-
J5P21_RS10300 (J5P21_10300)	2161151..2161555	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J5P21_RS10305 (J5P21_10305)	2161648..2161830	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
J5P21_RS10310 (J5P21_10310)	2162156..2162671	-	516	WP_009517104.1	hypothetical protein	-
J5P21_RS10315 (J5P21_10315)	2162741..2163658	-	918	WP_042774720.1	phage tail tube protein	-
J5P21_RS10320 (J5P21_10320)	2163711..2164682	-	972	WP_045544023.1	hypothetical protein	-
J5P21_RS10325 (J5P21_10325)	2164682..2165035	-	354	WP_002055486.1	hypothetical protein	-
J5P21_RS10330 (J5P21_10330)	2165132..2165653	-	522	WP_002055493.1	SH3 domain-containing protein	-
J5P21_RS10335 (J5P21_10335)	2165762..2165980	-	219	WP_002132566.1	hypothetical protein	-
J5P21_RS10340 (J5P21_10340)	2165982..2166380	-	399	WP_045544022.1	phage tail terminator-like protein	-
J5P21_RS10345 (J5P21_10345)	2166382..2166750	-	369	WP_032016325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2135168..2192260	57092

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T197357 WP_000838146.1 NZ_CP072122:c2161830-2161648 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T197357 NZ_CP096039:310640-310921 [Rhodococcus pyridinivorans]
ATGCGGCAGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGCGAGGCGAAAGGGCAGCACCGGGCCACGCTCGA
CGCCGACCTGGTGCCCGTCCTGGTCGCGCTCGCCGACGACCAGCCGCTGGAACCTCGGCACCGCGACCACGCGCTGACCG
GGGACTGGAAGGATCACCGGGATTGCCACGTCAAGCCCGACCTGGTGCTGATCTACCAGAAGCCCGACGCCGACACGCTG
CGCCTGGTGCGCCTCGGCTCTCACTCCGAACTCGGCTTGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT197357 WP_000966688.1 NZ_CP072122:c2161555-2161151 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT197357 NZ_CP096039:310390-310653 [Rhodococcus pyridinivorans]
ATGGCTGCAAACCAGCTCGTACAAACGCGCATCGACGGCGCGATCAAGGAAGAAGCGGCGGCCGTCCTGGCCGCGATGGG
CCTTACCGTGTCCGACGCGGTGCGGCTGCTGCTCACGAAGGTGGCCCAGGACAAGGCGCTGCCCTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCCCGCAAGGGCAAGCTGCCGCGCTTCGCCACCGTCAACGATCTGATG
GCCGATCTGCATGCGGCAGATTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6