Detailed information of TA system TA197355

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 875548..876227
• Replicon: chromosome
• Accession: NZ_CP072122
• Organism: Acinetobacter baumannii strain KSK1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: J5P21_RS04205
• Protein ID: WP_000838146.1
• Coordinates: 875548..875730 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: J5P21_RS04210
• Protein ID: WP_000966688.1
• Coordinates: 875823..876227 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5P21_RS04165 (J5P21_04165)	870883..871287	+	405	WP_045544425.1	hypothetical protein	-
J5P21_RS04170 (J5P21_04170)	871259..871627	+	369	WP_001993865.1	hypothetical protein	-
J5P21_RS04175 (J5P21_04175)	871629..872027	+	399	WP_002062850.1	phage tail terminator-like protein	-
J5P21_RS04180 (J5P21_04180)	872029..872247	+	219	WP_002002228.1	hypothetical protein	-
J5P21_RS04185 (J5P21_04185)	872343..872696	+	354	WP_032051762.1	hypothetical protein	-
J5P21_RS04190 (J5P21_04190)	872696..873667	+	972	WP_032051761.1	hypothetical protein	-
J5P21_RS04195 (J5P21_04195)	873720..874637	+	918	WP_000094273.1	phage tail tube protein	-
J5P21_RS04200 (J5P21_04200)	874707..875222	+	516	WP_001185592.1	hypothetical protein	-
J5P21_RS04205 (J5P21_04205)	875548..875730	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
J5P21_RS04210 (J5P21_04210)	875823..876227	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J5P21_RS04215 (J5P21_04215)	876326..877006	+	681	WP_000721572.1	hypothetical protein	-
J5P21_RS04220 (J5P21_04220)	877008..877271	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	850082..891697	41615

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T197355 WP_000838146.1 NZ_CP072122:875548-875730 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T197355 NZ_CP096035:665524-665802 [Rhodococcus pyridinivorans]
ATGAGCACTCCGGACCACCCGTATCGGCTGGTGATGGCGAGGTCGGCTGCACGCGCCATGGCGAGGTCGTTGCCGGAGAA
GGTAGCAACTGCGGTATACGAGTTCGTCACAGGACCCCTTCTCGAGAATCCGAAGCGGGTGGGGAAGCCGTTGAATCCGC
CTCTTGCGCCGGCGTACAGCGCCCGGCGAGGTGAATATCGCGTCCTGTATCTGATCGATGATGCGAACCGCACGGTCGAG
GTCACCGCGATTTCGCACCGTGCCGATGCGTATCGATAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT197355 WP_000966688.1 NZ_CP072122:875823-876227 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT197355 NZ_CP096035:665243-665527 [Rhodococcus pyridinivorans]
ATGACGACTCTTCCTGTTGCCGACGCGCGGGCGCAATTGTCACGACTGGTCGATGAGGCCGAGCGCACACACGAGCGATT
CGAGATCACCCGCAACGGGCACCGCGCCGCGGTGCTTCTCGGTGCCGACGATTACGACGCGATGCAGGAGACGATCGCGG
TGTTGTCGGATACGGATCTGCTGCGGGCGCACGTCGAGGGCCGAACGGAGGTCGAGTCGGGAGACGTCGTCGATGTACAG
GAATTGACGCAGCTGATGCGTGATGCTCGGTCGTCCGAGGAATGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6