Detailed information of TA system TA197351

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 5048103..5048922
• Replicon: chromosome
• Accession: NZ_CP072119
• Organism: Klebsiella michiganensis strain 12084

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: J5O09_RS23905
• Protein ID: WP_004110819.1
• Coordinates: 5048665..5048922 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: J5O09_RS23900
• Protein ID: WP_047684097.1
• Coordinates: 5048103..5048654 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5O09_RS23875 (J5O09_23870)	5044027..5044800	+	774	WP_103433587.1	Zygote formation protein zyg1	-
J5O09_RS23880 (J5O09_23875)	5045111..5045584	+	474	WP_032693194.1	hypothetical protein	-
J5O09_RS23885 (J5O09_23880)	5045853..5046202	-	350	Protein_4715	type II toxin-antitoxin system VapC family toxin	-
J5O09_RS23890 (J5O09_23885)	5046265..5046423	-	159	Protein_4716	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
J5O09_RS29670	5046457..5047203	-	747	WP_223226754.1	class I SAM-dependent methyltransferase	-
J5O09_RS29675	5047579..5047989	-	411	Protein_4718	class I SAM-dependent methyltransferase	-
J5O09_RS23900 (J5O09_23895)	5048103..5048654	-	552	WP_047684097.1	N-acetyltransferase	Antitoxin
J5O09_RS23905 (J5O09_23900)	5048665..5048922	-	258	WP_004110819.1	YjhX family toxin	Toxin
J5O09_RS23910 (J5O09_23905)	5049598..5050782	+	1185	WP_014228054.1	mannonate dehydratase	-
J5O09_RS23915 (J5O09_23910)	5050856..5052331	+	1476	WP_119834689.1	fructuronate reductase	-
J5O09_RS23920 (J5O09_23915)	5052470..5053246	+	777	WP_004847986.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (22-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T197351 WP_004110819.1 NZ_CP072119:c5048922-5048665 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T197351 NZ_CP096032:975608-976042 [Synechococcus sp. A10-1-5-1]
ATGGCGAAAGCGACAGCCCTCCTGGACGTCAATGTTCTGATTGCCCTTCTCGATCCGCAACACGTTCACCACGAGCTCTG
CCATGGCTGGTTCGCGAGCCGGGGCGATGCCCCCTGGGCCAGTTGCGCCATCACCCAAAACGCTGTGCTGCGGATCCTTG
GCAATCCGCGCTATCCCAACTCCCCAGGTCCGCCGGCCAGCGTGGCGCCCCACCTCGACAGCCTGGTGGGACATCCCAAC
CATCAATTCTGGGAAAGCAATCCGAGCTTGCTCGGCCAACCGTTCATCGAACGTTCCGCGTTGGTCGATCACGCGCAGAT
CACAGATCTCTACCTGCTTGCACTGGCCAAGCATCACGGCGGAACACTGGCCACCCTCGATCAACGCATCCAGGTCAAGA
AAGGAGAGCAAGGGTTGGAGCTGATTCGCCCCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19842.60 Da
• Isoelectric Point: 6.4897

>AT197351 WP_047684097.1 NZ_CP072119:c5048654-5048103 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAACYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT197351 NZ_CP096032:975369-975608 [Synechococcus sp. A10-1-5-1]
ATGCGTACGACCTTGTCCCTCGACGACGACGTCCTTGCGGCAGCCAAGGTGCTGGCGCGACAACGCAAGCAACCGATTGG
CAGCGTGATCAGCGACCTCGCTCGCGAAGGATTAGCGCAGGCCAATCGGAAGAACCAGGAGACCCCAAAGGCCAGGCGCA
ATGGCCTGGCGCTGCTTCCCCGACGCGCAGATGGATCCCCTGTGGACTTGGAGCTAGTGAACAGCCTGCGGGAGGACTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2