Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1555207..1555990 Replicon chromosome
Accession NZ_CP072119
Organism Klebsiella michiganensis strain 12084

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag J5O09_RS07600 Protein ID WP_039077579.1
Coordinates 1555207..1555581 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag J5O09_RS07605 Protein ID WP_039077578.1
Coordinates 1555631..1555990 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5O09_RS07575 (J5O09_07575) 1550661..1551569 + 909 WP_032938037.1 kdo(2)-lipid IV(A) palmitoleoyltransferase -
J5O09_RS07580 (J5O09_07580) 1552343..1552816 + 474 WP_228291928.1 glycosyltransferase family 2 protein -
J5O09_RS07585 (J5O09_07585) 1552892..1554120 + 1229 WP_104159316.1 IS3 family transposase -
J5O09_RS07590 (J5O09_07590) 1554105..1554668 + 564 WP_228291929.1 hypothetical protein -
J5O09_RS07595 (J5O09_07595) 1554672..1555130 + 459 WP_224232182.1 hypothetical protein -
J5O09_RS07600 (J5O09_07600) 1555207..1555581 - 375 WP_039077579.1 TA system toxin CbtA family protein Toxin
J5O09_RS07605 (J5O09_07605) 1555631..1555990 - 360 WP_039077578.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J5O09_RS07610 (J5O09_07610) 1556013..1556234 - 222 WP_032938028.1 DUF987 domain-containing protein -
J5O09_RS07615 (J5O09_07615) 1556248..1556730 - 483 WP_039077577.1 DNA repair protein RadC -
J5O09_RS07620 (J5O09_07620) 1556971..1557450 - 480 WP_082027055.1 antirestriction protein -
J5O09_RS07625 (J5O09_07625) 1557530..1558351 - 822 WP_039077576.1 DUF932 domain-containing protein -
J5O09_RS07630 (J5O09_07630) 1558462..1558674 - 213 WP_032938024.1 hypothetical protein -
J5O09_RS07635 (J5O09_07635) 1558784..1559257 - 474 WP_032938022.1 hypothetical protein -
J5O09_RS07640 (J5O09_07640) 1559331..1559960 - 630 WP_039077575.1 hypothetical protein -
J5O09_RS07645 (J5O09_07645) 1560058..1560735 - 678 WP_039077574.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1525294..1578271 52977


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(9-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13875.91 Da        Isoelectric Point: 10.3681

>T197340 WP_039077579.1 NZ_CP072119:c1555581-1555207 [Klebsiella michiganensis]
MQKQSLSPHRAASSRLSSVEIWRKLLKYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCYAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSIDMLRARKATGLMTRKGYKTVTDISGGRSSGGK

Download         Length: 375 bp

>T197340 NZ_CP096018:c859044-858700 [Alkalimarinus coralli]
ATGAAGGCAGTATTTATAGAGTTACCGCCATTTGAGCGGAATAGAGGGCACTATTTAGATGACAATGCTTACCGTAATTT
TCAAAATGAGATACTGAAAAATCCTACATCTGGTGATTTAATAAAAGGGACTTGCGGACTGCGAAAAGTGCGTTATAAGG
ATGAACGTAGACGAAAAGGAAAGCGTGGTGGTGTTAGGGTTATCTACTATTGGTGGAAAGAAGGATCACAGTTTTGGCTT
TTTACCATTTACGACAAAGATGAAGTTACAGACCTTACCAAAGCTGAGCTGAAGTTATTGGCAGACTTGTTGAAGCTTGA
AATTAAAGCGAGAAGCTTATTATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13317.39 Da        Isoelectric Point: 7.4144

>AT197340 WP_039077578.1 NZ_CP072119:c1555990-1555631 [Klebsiella michiganensis]
MQKATRVINHNIAEPWWGLRRNITPCFGARLVHEGNHLHYLADRASIAGTFNDADLRHLDQAFPVLMKQMELMLTSSELT
PHIQRCITLHAKGLICEADTLGSCGYLYIVIYPASATTA

Download         Length: 360 bp

>AT197340 NZ_CP096018:c858703-858392 [Alkalimarinus coralli]
ATGAAACGTAATTTATTCGAAGAATTAAGTGAAGGGTTCCAGTCTTTAAAGGATGATAGAGAAGGGAAAACTACCCTAAA
ACAGCACTTGGTGATGGCGACAGAAACGCCTGAGGTGACTAGCGAGGAGCTAATCAGTTTAAGGGAAAGGTTGCACTTAT
CACAGGCTGTTTTTGCTGATTTTTTAAGAATCAATAAAAGAACATTAGAAAATTGGGAGCAAGGCCGAGTTAAACCAAAC
TCACAGGCAGCTCTGCTTATCAAAATGGTTGAAAAATACCCAGACACCATTCAACGGTTAGGTACTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References