Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1066644..1067301 Replicon chromosome
Accession NZ_CP072119
Organism Klebsiella michiganensis strain 12084

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag J5O09_RS05260 Protein ID WP_004854060.1
Coordinates 1066891..1067301 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag J5O09_RS05255 Protein ID WP_004124953.1
Coordinates 1066644..1066910 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5O09_RS05240 (J5O09_05240) 1061878..1062303 - 426 WP_032720093.1 PTS sugar transporter subunit IIA -
J5O09_RS05245 (J5O09_05245) 1062424..1065222 - 2799 WP_014226794.1 transcriptional regulator DagR -
J5O09_RS05250 (J5O09_05250) 1065416..1066399 - 984 WP_032720095.1 tRNA-modifying protein YgfZ -
J5O09_RS05255 (J5O09_05255) 1066644..1066910 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
J5O09_RS05260 (J5O09_05260) 1066891..1067301 + 411 WP_004854060.1 protein YgfX Toxin
J5O09_RS05265 (J5O09_05265) 1067310..1067831 - 522 WP_014226792.1 flavodoxin FldB -
J5O09_RS05270 (J5O09_05270) 1067953..1068849 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
J5O09_RS05275 (J5O09_05275) 1068872..1069585 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J5O09_RS05280 (J5O09_05280) 1069591..1071324 + 1734 WP_038423602.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T197339 WP_004854060.1 NZ_CP072119:1066891-1067301 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

>T197339 NZ_CP096018:c182869-182585 [Alkalimarinus coralli]
GTGATTTATTGGGAGGAAGAGTCTCTAAACGACCGCGAAAGGATATTCGAATTTCTTTATGACTTTAATCCAATAGCAGC
AGAGAAAACAGATAAAATCATCGAGGAAAAAGTTGAAAACCTACATCAGCAGCCTTTAATGGGCGTGCAACGCGGTGGCA
TTCAAGGCCGCTTGCTAGTCATTCCAGAAATATCAATGATCGTATCCTACTGGACTGACAATACCGTGATACGGGTTATG
AGAGTCCTTCATCAGAAACAAAAATTTCCGGCTAAAAGACCGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT197339 WP_004124953.1 NZ_CP072119:1066644-1066910 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT197339 NZ_CP096018:c183151-182873 [Alkalimarinus coralli]
ATGGATACTAGAGTTCAATTTCGAATTGATGAAGAAACTAAGCGCCTAGCCCAACAAAGGACAGAAAGCCAAGGGCGCAC
ACTTAGTGATGCATGTCGAGAACTTACAGAACAACTAGCAGATCAACAGCGTAAAGCCACTTCTCATGATGCTTGGCTGA
CTGAACAAGTTAATTTGGCTTTTGAAAAGTTTCAGACCAACAGATCAACTTTTGTTGAGCATGAACACGCGAAATCCAGT
ATGTCAGAGCGCAAAGCCAAAATACGTGAAAGGTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References