Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 908523..909276 Replicon chromosome
Accession NZ_CP072119
Organism Klebsiella michiganensis strain 12084

Toxin (Protein)


Gene name yeeV Uniprot ID R8WN26
Locus tag J5O09_RS04445 Protein ID WP_016154457.1
Coordinates 908523..908900 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag J5O09_RS04450 Protein ID WP_162838704.1
Coordinates 908950..909276 (-) Length 109 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5O09_RS04415 (J5O09_04415) 903812..904603 - 792 Protein_869 IS630-like element ISSpu2 family transposase -
J5O09_RS04420 (J5O09_04420) 904775..905059 - 285 WP_008913927.1 hypothetical protein -
J5O09_RS04425 (J5O09_04425) 905168..906439 - 1272 WP_004856926.1 integrase arm-type DNA-binding domain-containing protein -
J5O09_RS04430 (J5O09_04430) 906876..907721 - 846 Protein_872 DUF4942 domain-containing protein -
J5O09_RS04435 (J5O09_04435) 907802..908005 - 204 WP_009652505.1 DUF957 domain-containing protein -
J5O09_RS04440 (J5O09_04440) 908035..908526 - 492 WP_009652438.1 DUF5983 family protein -
J5O09_RS04445 (J5O09_04445) 908523..908900 - 378 WP_016154457.1 TA system toxin CbtA family protein Toxin
J5O09_RS04450 (J5O09_04450) 908950..909276 - 327 WP_162838704.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J5O09_RS04455 (J5O09_04455) 909333..909554 - 222 WP_009652392.1 DUF987 domain-containing protein -
J5O09_RS04460 (J5O09_04460) 909568..910050 - 483 WP_016154455.1 DNA repair protein RadC -
J5O09_RS04465 (J5O09_04465) 910062..910280 - 219 WP_009652503.1 hypothetical protein -
J5O09_RS04470 (J5O09_04470) 910291..910764 - 474 WP_009652453.1 antirestriction protein -
J5O09_RS04475 (J5O09_04475) 910781..911035 - 255 WP_009652519.1 hypothetical protein -
J5O09_RS04480 (J5O09_04480) 911035..911853 - 819 WP_009652424.1 DUF932 domain-containing protein -
J5O09_RS04485 (J5O09_04485) 911957..912190 - 234 WP_009652474.1 DUF905 domain-containing protein -
J5O09_RS04490 (J5O09_04490) 912246..912467 - 222 WP_009652443.1 hypothetical protein -
J5O09_RS04495 (J5O09_04495) 912550..913062 - 513 WP_009652395.1 DUF4234 domain-containing protein -
J5O09_RS04500 (J5O09_04500) 913111..913581 - 471 WP_009652431.1 hypothetical protein -
J5O09_RS04505 (J5O09_04505) 913628..913939 - 312 WP_009652410.1 hypothetical protein -
J5O09_RS04510 (J5O09_04510) 913952..914218 - 267 WP_009652486.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(4-103)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14168.19 Da        Isoelectric Point: 9.5224

>T197338 WP_016154457.1 NZ_CP072119:c908900-908523 [Klebsiella michiganensis]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Download         Length: 378 bp

>T197338 NZ_CP096018:c177203-176886 [Alkalimarinus coralli]
ATGACACAATTTACTCTATATAAAAACGAAGACAGAAGTTCTCGAAAAACTTACCCATATTTTGTTAATGTACAAAGCGA
CTTACTCAAAGACCTAAACTCCCGTTTAGTAATTCCCCTTTCGCCAGGTTCAGCAGTAAATAACACGAACGCAAAAAAAC
TTTGCCCCATTATCAACCTAGACGAAGGAAGCTTTATACTTTTGGCCCATCAAATGACATCGGTGCCGAGGTCTATATTG
AAGGCTGAAGTTACTTCTCTTGAGAGCTACAGGTACGAAATTATGGATGCTATTGATATGCTCATAACCGGCATTTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12079.85 Da        Isoelectric Point: 6.6283

>AT197338 WP_162838704.1 NZ_CP072119:c909276-908950 [Klebsiella michiganensis]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE

Download         Length: 327 bp

>AT197338 NZ_CP096018:c177448-177203 [Alkalimarinus coralli]
ATGCAACAAGCCTTCAATGAAAATGCACCTAAAAAAGCAACTAATTTAAGCATCAATAGCGATCTTCTTAATAAGGCTCG
CGGCCTTAAAATTAACCTTTCTGCGACCCTTGAGCAAGCCTTAACTATACAAGTAAGAAACGCTGAAAGAGAACTTTGGG
TAGAAGAGAACAAAGAAGCAATTCAAGCCTTAAACGAGTTAGCCGATAAAAATGGATTATTTTCAGACTCTTTTCGAGAC
TTCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB R8WN26


Antitoxin

Source ID Structure

References