Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 753016..753719 Replicon chromosome
Accession NZ_CP072119
Organism Klebsiella michiganensis strain 12084

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag J5O09_RS03650 Protein ID WP_119834388.1
Coordinates 753378..753719 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag J5O09_RS03645 Protein ID WP_119834410.1
Coordinates 753016..753357 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5O09_RS03605 (J5O09_03605) 748568..749272 + 705 WP_119834393.1 WYL domain-containing protein -
J5O09_RS03610 (J5O09_03610) 749272..749841 + 570 WP_119834392.1 hypothetical protein -
J5O09_RS03615 (J5O09_03615) 749856..750308 + 453 WP_100168667.1 hypothetical protein -
J5O09_RS03620 (J5O09_03620) 750305..750754 + 450 WP_071199563.1 IrmA family protein -
J5O09_RS03625 (J5O09_03625) 750826..751056 + 231 WP_119834391.1 DUF905 domain-containing protein -
J5O09_RS03630 (J5O09_03630) 751155..751976 + 822 WP_119834390.1 DUF932 domain-containing protein -
J5O09_RS03635 (J5O09_03635) 752007..752450 + 444 WP_025205062.1 antirestriction protein -
J5O09_RS03640 (J5O09_03640) 752463..753005 + 543 WP_119834389.1 DNA repair protein RadC -
J5O09_RS03645 (J5O09_03645) 753016..753357 + 342 WP_119834410.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J5O09_RS03650 (J5O09_03650) 753378..753719 + 342 WP_119834388.1 TA system toxin CbtA family protein Toxin
J5O09_RS03660 (J5O09_03660) 754081..754587 + 507 WP_009651862.1 G/U mismatch-specific DNA glycosylase -
J5O09_RS03665 (J5O09_03665) 754657..755319 - 663 WP_032692890.1 TetR/AcrR family transcriptional regulator -
J5O09_RS03670 (J5O09_03670) 755560..757404 - 1845 WP_004105908.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12850.81 Da        Isoelectric Point: 9.6542

>T197337 WP_119834388.1 NZ_CP072119:753378-753719 [Klebsiella michiganensis]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLRRSRNNAVS

Download         Length: 342 bp

>T197337 NZ_CP096017:4317179-4317442 [Alkalimarinus coralli]
ATGAGTAGCCGGTTACTTGTATGGACTGATGAAGCGTGGAGTGACTATTTGTATTGGCAAGGTCAGGATAAAAAGACGCT
AAAGCGTATTAACAAGCTTATCAGTGACTCCAAGAGAGCACCGTTCGAGGGGATAGGTAAACCAGAACCGTTAAAAGAGT
ACCTGTCTGGTTTTTGGTCTCGCAGAATTGATGATACAAATAGGTTGGTATATGCAGTAGATAATACATCACTAACAGTT
ATTTCTTGCAGATACCACTACTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12932.51 Da        Isoelectric Point: 5.9608

>AT197337 WP_119834410.1 NZ_CP072119:753016-753357 [Klebsiella michiganensis]
MKSTDSENDSFLKWGLNRNETPCFGARLVQEGNRLHYLANRASITGEFINTEYLKLDEIFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYISVYPTQR

Download         Length: 342 bp

>AT197337 NZ_CP096017:4316932-4317186 [Alkalimarinus coralli]
ATGAAAATTGTATCTTTTACTGAAGCTCGCAATGGTTTAAAGGCTGTTTTGGATTCCGTTGTAAACGATGCAGATTCAGC
GATTATTACTCGCCGTGACTCTGAAGATGCTGTTGTAATGTCATTAAATTACTACAACAGTTTAATGGAAACTGTTCACT
TATTAAGATCCCCGGCTAATGCTGAGCATTTAGCCAAGTCTATTGATCAATTTAGAAAAGGGTCTGCCACTCCCAGAGAT
CTAATAGATGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References