Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 8816341..8817002 Replicon chromosome
Accession NZ_CP072117
Organism Cohnella sp. LGH

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J4772_RS36440 Protein ID WP_209073633.1
Coordinates 8816583..8817002 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J4772_RS36435 Protein ID WP_116060922.1
Coordinates 8816341..8816586 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4772_RS36415 (J4772_36415) 8811378..8812142 - 765 WP_209073631.1 two-component system regulatory protein YycI -
J4772_RS36420 (J4772_36420) 8812174..8813499 - 1326 WP_116060920.1 two-component system activity regulator YycH -
J4772_RS36425 (J4772_36425) 8813496..8815319 - 1824 WP_209073632.1 cell wall metabolism sensor histidine kinase WalK -
J4772_RS36430 (J4772_36430) 8815316..8816056 - 741 WP_147310178.1 response regulator YycF -
J4772_RS36435 (J4772_36435) 8816341..8816586 + 246 WP_116060922.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J4772_RS36440 (J4772_36440) 8816583..8817002 + 420 WP_209073633.1 type II toxin-antitoxin system VapC family toxin Toxin
J4772_RS36445 (J4772_36445) 8817062..8817646 - 585 WP_209073634.1 TIGR00730 family Rossman fold protein -
J4772_RS36450 (J4772_36450) 8817941..8819380 - 1440 WP_209073635.1 IS66 family transposase -
J4772_RS36455 (J4772_36455) 8819481..8819666 + 186 WP_209073636.1 helix-turn-helix transcriptional regulator -
J4772_RS36460 (J4772_36460) 8820066..8820332 - 267 WP_116060925.1 hypothetical protein -
J4772_RS36465 (J4772_36465) 8820443..8820667 + 225 WP_209073637.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-61)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15768.23 Da        Isoelectric Point: 5.6595

>T197326 WP_209073633.1 NZ_CP072117:8816583-8817002 [Cohnella sp. LGH]
MKYLLDTNVISELIKKEPNLGVLNWMDERDESALFLSVITFGELQKGISKLSDKDRAARLQVWIDQDLTERFHGRTLSLD
LNILMTWGQIQGNSEKVGIALPVMDSLIAATAITHNLTVVTRNVKDIERCQVPVHNPWI

Download         Length: 420 bp

>T197326 NZ_CP096017:c184279-183995 [Alkalimarinus coralli]
GTGATTTATTGGGAGGAAGAGTCTCTAAACGACCGCGAAAGGATATTCGAATTTCTTTATGACTTTAATCCAATAGCAGC
AGAGAAAACAGATAAAATCATCGAGGAAAAAGTTGAAAACCTACATCAGCAGCCTTTAATGGGCGTGCAACGCGGTGGCA
TTCAAGGCCGCTTGCTAGTCATTCCAGAAATATCAATGATCGTATCCTACTGGACTGACAATACCGTGATACGGGTTATG
AGAGTCCTTCATCAGAAACAAAAATTTCCGGCTAAAAGACCGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9494.82 Da        Isoelectric Point: 7.0146

>AT197326 WP_116060922.1 NZ_CP072117:8816341-8816586 [Cohnella sp. LGH]
MQWQLQDAKNQLSSVVKRATDEGPQIISVRGRPAAIVLSMEEYHRLTKPKTRLTDFFKNSPFRELELDLERNQDVPREVE
L

Download         Length: 246 bp

>AT197326 NZ_CP096017:c184561-184283 [Alkalimarinus coralli]
ATGGATACTAGAGTTCAATTTCGAATTGATGAAGAAACTAAGCGCCTAGCCCAACAAAGGACAGAAAGCCAAGGGCGCAC
ACTTAGTGATGCATGTCGAGAACTTACAGAACAACTAGCAGATCAACAGCGTAAAGCCACTTCTCATGATGCTTGGCTGA
CTGAACAAGTTAATTTGGCTTTTGAAAAGTTTCAGACCAACAGATCAACTTTTGTTGAGCATGAACACGCGAAATCCAGT
ATGTCAGAGCGCAAAGCCAAAATACGTGAAAGGTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References