Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1109694..1110329 Replicon chromosome
Accession NZ_CP072117
Organism Cohnella sp. LGH

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag J4772_RS04380 Protein ID WP_116060158.1
Coordinates 1109694..1110044 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag J4772_RS04385 Protein ID WP_116060157.1
Coordinates 1110048..1110329 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4772_RS04370 (J4772_04370) 1105239..1108364 - 3126 WP_209074283.1 ATP-binding protein -
J4772_RS04375 (J4772_04375) 1108367..1109602 - 1236 WP_209074284.1 aminopeptidase -
J4772_RS04380 (J4772_04380) 1109694..1110044 - 351 WP_116060158.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
J4772_RS04385 (J4772_04385) 1110048..1110329 - 282 WP_116060157.1 ribbon-helix-helix protein, CopG family Antitoxin
J4772_RS04390 (J4772_04390) 1110464..1111651 - 1188 WP_209074285.1 alanine racemase -
J4772_RS04395 (J4772_04395) 1111846..1113006 - 1161 WP_209074286.1 outer membrane lipoprotein carrier protein LolA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12900.89 Da        Isoelectric Point: 5.5728

>T197325 WP_116060158.1 NZ_CP072117:c1110044-1109694 [Cohnella sp. LGH]
MIVKRGDVFYADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIIAAITAQIQKAKLPTHVEIEAKTHGMERDSVILLEQI
RTIDKQRLTDKITHLDDETMHKVDDALQISVGLIDF

Download         Length: 351 bp

>T197325 NZ_CP096017:c178613-178296 [Alkalimarinus coralli]
ATGACACAATTTACTCTATATAAAAACGAAGACAGAAGTTCTCGAAAAACTTACCCATATTTTGTTAATGTACAAAGCGA
CTTACTCAAAGACCTAAACTCCCGTTTAGTAATTCCCCTTTCGCCAGGTTCAGCAGTAAATAACACGAACGCAAAAAAAC
TTTGCCCCATTATCAACCTAGACGAAGGAAGCTTTATACTTTTGGCCCATCAAATGACATCGGTGCCGAGGTCTATATTG
AAGGCTGAAGTTACTTCTCTTGAGAGCTACAGGTACGAAATTATGGATGCTATTGATATGCTCATAACCGGCATTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10752.46 Da        Isoelectric Point: 9.6917

>AT197325 WP_116060157.1 NZ_CP072117:c1110329-1110048 [Cohnella sp. LGH]
VANLHNTKRIMISLPDHLLREVDFVVAKENTNRSEIVRQAMKHYLVDRKKRLIRDAMQRGYLEMAKINLHMASEAFHAEE
DADNILGRLVSGV

Download         Length: 282 bp

>AT197325 NZ_CP096017:c178858-178613 [Alkalimarinus coralli]
ATGCAACAAGCCTTCAATGAAAATGCACCTAAAAAAGCAACTAATTTAAGCATCAATAGCGATCTTCTTAATAAGGCTCG
CGGCCTTAAAATTAACCTTTCTGCGACCCTTGAGCAAGCCTTAACTATACAAGTAAGAAACGCTGAAAGAGAACTTTGGG
TAGAAGAGAACAAAGAAGCAATTCAAGCCTTAAACGAGTTAGCCGATAAAAATGGATTATTTTCAGACTCTTTTCGAGAC
TTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References