Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2778298..2778812 Replicon chromosome
Accession NZ_CP072116
Organism Staphylococcus aureus strain TCH32929

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag J6L63_RS13890 Protein ID WP_000581792.1
Coordinates 2778603..2778812 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag J6L63_RS13885 Protein ID WP_000138932.1
Coordinates 2778298..2778591 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6L63_RS13865 (2773461) 2773461..2774102 + 642 WP_000483153.1 thiamine phosphate synthase -
J6L63_RS13870 (2774188) 2774188..2775060 + 873 WP_000725802.1 membrane protein insertase YidC -
J6L63_RS13875 (2775973) 2775973..2776620 - 648 WP_001187630.1 HD domain-containing protein -
J6L63_RS13880 (2776648) 2776648..2778132 - 1485 WP_000571549.1 cardiolipin synthase -
J6L63_RS13885 (2778298) 2778298..2778591 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
J6L63_RS13890 (2778603) 2778603..2778812 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
J6L63_RS13895 (2778940) 2778940..2779077 + 138 WP_000828354.1 Lmo0850 family protein -
J6L63_RS13900 (2779341) 2779341..2780543 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
J6L63_RS13905 (2780861) 2780861..2781931 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
J6L63_RS13910 (2781946) 2781946..2783304 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T197323 WP_000581792.1 NZ_CP072116:2778603-2778812 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T197323 NZ_CP096016:c4334103-4333852 [Alkalimarinus coralli]
ATGGACGCTATAAGCTACACACATGCTAGAGCAAACCTTTCAAGTACCATGGAGAAAGTTTGCAATGATCATGCCCCGAT
AATCATAACCCGTAAAAGTGAATCACCAGTAGTAATGATGTCACTTGAAGATTATCAAGCAATGGAAGAAACAACGTACT
TGCTGCGCTCTCCAGCAAATGCGAGACAATTATTAGAATCAATTGCTGAGCTAGAGTCTGGCAAAGGCACCGAGAGAGAG
CTACTTGAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT197323 WP_000138932.1 NZ_CP072116:2778298-2778591 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT197323 NZ_CP096016:c4333855-4333598 [Alkalimarinus coralli]
ATGAAAGTGACTTTCTCTTCTGCAGCTTGGGATCAGTACCTTTATTGGCAAACTACAGACAAAAAGATCCTAAAGCGCAT
TAACCAATTGATTAAAGATATAAAACGAGAGCCTTACGAAGGAATAGGTAAACCTGAGCCTTTAAAACATGGATTAGCTG
GCTACTGGTCTCGCCGCATTAACGATGAACATAGGATCGTTTATAAATACACAGAAGGCACGATCCTTATCGCACAGTTA
CGCTACCATTACACATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References