Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2404600..2405123 Replicon chromosome
Accession NZ_CP072116
Organism Staphylococcus aureus strain TCH32929

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag J6L63_RS11955 Protein ID WP_000074049.1
Coordinates 2404857..2405123 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag J6L63_RS11950 Protein ID WP_000587616.1
Coordinates 2404600..2404857 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6L63_RS11935 (2401097) 2401097..2401846 - 750 WP_000072461.1 CPBP family lipoprotein N-acylation protein LnsB -
J6L63_RS11940 (2402041) 2402041..2403618 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
J6L63_RS11945 (2403786) 2403786..2404241 - 456 WP_000732076.1 DUF1307 domain-containing protein -
J6L63_RS11950 (2404600) 2404600..2404857 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J6L63_RS11955 (2404857) 2404857..2405123 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
J6L63_RS11960 (2405478) 2405478..2406554 + 1077 WP_001076673.1 M42 family metallopeptidase -
J6L63_RS11965 (2406802) 2406802..2407464 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
J6L63_RS11970 (2407457) 2407457..2408233 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
J6L63_RS11975 (2408629) 2408629..2409816 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T197315 WP_000074049.1 NZ_CP072116:2404857-2405123 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T197315 NZ_CP096016:c1599233-1598949 [Alkalimarinus coralli]
GTGATTTATTGGGAGGAAGAGTCTCTAAACGACCGCGAAAGGATATTCGAATTTCTTTATGACTTTAATCCAATAGCAGC
AGAGAAAACAGATAAAATCATCGAGGAAAAAGTTGAAAACCTACATCAGCAGCCTTTAATGGGCGTGCAACGCGGTGGCA
TTCAAGGCCGCTTGCTAGTCATTCCAGAAATATCAATGATCGTATCCTACTGGACTGACAATACCGTGATACGGGTTATG
AGAGTCCTTCATCAGAAACAAAAATTTCCGGCTAAAAGACCGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT197315 WP_000587616.1 NZ_CP072116:2404600-2404857 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT197315 NZ_CP096016:c1599515-1599237 [Alkalimarinus coralli]
ATGGATACTAGAGTTCAATTTCGAATTGATGAAGAAACTAAGCGCCTAGCCCAACAAAGGACAGAAAGCCAAGGGCGCAC
ACTTAGTGATGCATGTCGAGAACTTACAGAACAACTAGCAGATCAACAGCGTAAAGCCACTTCTCATGATGCTTGGCTGA
CTGAACAAGTTAATTTGGCTTTTGAAAAGTTTCAGACCAACAGATCAACTTTTGTTGAGCATGAACACGCGAAATCCAGT
ATGTCAGAGCGCAAAGCCAAAATACGTGAAAGGTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References