Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1251147..1251624 Replicon chromosome
Accession NZ_CP072116
Organism Staphylococcus aureus strain TCH32929

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag J6L63_RS06490 Protein ID WP_000052076.1
Coordinates 1251436..1251624 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag J6L63_RS06485 Protein ID WP_001059690.1
Coordinates 1251147..1251407 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6L63_RS06450 (1246540) 1246540..1247256 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
J6L63_RS06455 (1247404) 1247404..1247826 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
J6L63_RS06460 (1248225) 1248225..1248719 + 495 WP_000569883.1 GNAT family N-acetyltransferase -
J6L63_RS06465 (1248874) 1248874..1249491 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
J6L63_RS06470 (1249564) 1249564..1250145 - 582 WP_001140693.1 histidine phosphatase family protein -
J6L63_RS06475 (1250370) 1250370..1250606 + 237 WP_000349581.1 hypothetical protein -
J6L63_RS06480 (1250603) 1250603..1250806 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
J6L63_RS06485 (1251147) 1251147..1251407 + 261 WP_001059690.1 hypothetical protein Antitoxin
J6L63_RS06490 (1251436) 1251436..1251624 + 189 WP_000052076.1 hypothetical protein Toxin
J6L63_RS06495 (1251812) 1251812..1252381 + 570 WP_001106658.1 lipoprotein N-acylation protein LnsA -
J6L63_RS06500 (1252469) 1252469..1252738 + 270 WP_001004398.1 hypothetical protein -
J6L63_RS06505 (1252815) 1252815..1253033 + 219 WP_000005886.1 hypothetical protein -
J6L63_RS06510 (1253525) 1253525..1253725 - 201 WP_001059082.1 cold-shock protein -
J6L63_RS06515 (1254082) 1254082..1254768 - 687 WP_000141557.1 thermonuclease family protein -
J6L63_RS06520 (1255109) 1255109..1255630 - 522 WP_244777081.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-104)

Antitoxin

Post-segregation antitoxin CcdA

(11-81)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T197314 WP_000052076.1 NZ_CP072116:1251436-1251624 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T197314 NZ_CP096016:c1593567-1593250 [Alkalimarinus coralli]
ATGACACAATTTACTCTATATAAAAACGAAGACAGAAGTTCTCGAAAAACTTACCCATATTTTGTTAATGTACAAAGCGA
CTTACTCAAAGACCTAAACTCCCGTTTAGTAATTCCCCTTTCGCCAGGTTCAGCAGTAAATAACACGAACGCAAAAAAAC
TTTGCCCCATTATCAACCTAGACGAAGGAAGCTTTATACTTTTGGCCCATCAAATGACATCGGTGCCGAGGTCTATATTG
AAGGCTGAAGTTACTTCTCTTGAGAGCTACAGGTACGAAATTATGGATGCTATTGATATGCTCATAACCGGCATTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT197314 WP_001059690.1 NZ_CP072116:1251147-1251407 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT197314 NZ_CP096016:c1593812-1593567 [Alkalimarinus coralli]
ATGCAACAAGCCTTCAATGAAAATGCACCTAAAAAAGCAACTAATTTAAGCATCAATAGCGATCTTCTTAATAAGGCTCG
CGGCCTTAAAATTAACCTTTCTGCGACCCTTGAGCAAGCCTTAACTATACAAGTAAGAAACGCTGAAAGAGAACTTTGGG
TAGAAGAGAACAAAGAAGCAATTCAAGCCTTAAACGAGTTAGCCGATAAAAATGGATTATTTTCAGACTCTTTTCGAGAC
TTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References