197304

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1013294..1013777 Replicon chromosome
Accession NZ_CP072115
Organism Streptococcus sp. zg-86

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J5M87_RS04890 Protein ID WP_154607893.1
Coordinates 1013517..1013777 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J5M87_RS04885 Protein ID WP_154607892.1
Coordinates 1013294..1013515 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5M87_RS04845 (J5M87_04845) 1008527..1008958 + 432 WP_154608546.1 hypothetical protein -
J5M87_RS04850 (J5M87_04850) 1009098..1010432 - 1335 WP_208769380.1 IS66 family transposase -
J5M87_RS04855 (J5M87_04855) 1010404..1010610 - 207 WP_208769381.1 hypothetical protein -
J5M87_RS04860 (J5M87_04860) 1010660..1011010 - 351 WP_208769382.1 IS66 family insertion sequence element accessory protein TnpB -
J5M87_RS04865 (J5M87_04865) 1010991..1011176 - 186 WP_154608075.1 hypothetical protein -
J5M87_RS04870 (J5M87_04870) 1011523..1011978 - 456 WP_160463146.1 helix-turn-helix domain-containing protein -
J5M87_RS04875 (J5M87_04875) 1012149..1012385 + 237 WP_154607890.1 hypothetical protein -
J5M87_RS04880 (J5M87_04880) 1012421..1013128 - 708 WP_154607891.1 alpha/beta hydrolase -
J5M87_RS04885 (J5M87_04885) 1013294..1013515 + 222 WP_154607892.1 DUF6290 family protein Antitoxin
J5M87_RS04890 (J5M87_04890) 1013517..1013777 + 261 WP_154607893.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J5M87_RS04895 (J5M87_04895) 1013930..1015477 - 1548 WP_154607894.1 glutamine-hydrolyzing GMP synthase -
J5M87_RS04900 (J5M87_04900) 1015607..1016305 + 699 WP_154607895.1 GntR family transcriptional regulator -
J5M87_RS04905 (J5M87_04905) 1016397..1016729 + 333 WP_154607896.1 putative DNA-binding protein -
J5M87_RS04910 (J5M87_04910) 1016741..1018306 + 1566 WP_154607897.1 signal recognition particle protein -
J5M87_RS04915 (J5M87_04915) 1018336..1018668 - 333 WP_160463147.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10303.94 Da        Isoelectric Point: 10.0734

>T197304 WP_154607893.1 NZ_CP072115:1013517-1013777 [Streptococcus sp. zg-86]
MYHIEYSKKAQKQIKKLDKPIQRLLFAWIDKHLEGTDNPRANGKGLTGNHAKEWRYRIGDYRLICHIQDDKLIILALEFG
HRRDIY

Download         Length: 261 bp

>T197304 NZ_CP095923:1913439-1914026 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGACGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGTGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8514.43 Da        Isoelectric Point: 4.4475

>AT197304 WP_154607892.1 NZ_CP072115:1013294-1013515 [Streptococcus sp. zg-86]
MSTVTIRLNQEEETFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYAEYQADSETISHADFKKELGL

Download         Length: 222 bp

>AT197304 NZ_CP095923:1914093-1914947 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTAGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTAGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTTGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References