Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 100330..100999 Replicon chromosome
Accession NZ_CP072115
Organism Streptococcus sp. zg-86

Toxin (Protein)


Gene name hicA Uniprot ID A0A917EGJ9
Locus tag J5M87_RS00650 Protein ID WP_068993248.1
Coordinates 100820..100999 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J5M87_RS00645 Protein ID WP_154607858.1
Coordinates 100330..100782 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5M87_RS00605 (J5M87_00605) 95674..96033 + 360 WP_230082345.1 DUF1033 family protein -
J5M87_RS00610 (J5M87_00610) 96244..97194 + 951 WP_160463143.1 competence type IV pilus ATPase ComGA -
J5M87_RS00615 (J5M87_00615) 97115..98143 + 1029 WP_258232202.1 competence type IV pilus assembly protein ComGB -
J5M87_RS00620 (J5M87_00620) 98145..98459 + 315 WP_154607862.1 competence type IV pilus major pilin ComGC -
J5M87_RS00625 (J5M87_00625) 98419..98847 + 429 WP_154607861.1 competence type IV pilus minor pilin ComGD -
J5M87_RS00630 (J5M87_00630) 98819..99112 + 294 WP_160463141.1 competence type IV pilus minor pilin ComGE -
J5M87_RS00635 (J5M87_00635) 99096..99533 + 438 WP_154607860.1 competence type IV pilus minor pilin ComGF -
J5M87_RS00640 (J5M87_00640) 99544..99969 + 426 WP_154607859.1 competence type IV pilus minor pilin ComGG -
J5M87_RS00645 (J5M87_00645) 100330..100782 - 453 WP_154607858.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J5M87_RS00650 (J5M87_00650) 100820..100999 - 180 WP_068993248.1 type II toxin-antitoxin system HicA family toxin Toxin
J5M87_RS00655 (J5M87_00655) 101183..101590 - 408 WP_154607857.1 ArpU family transcriptional regulator -
J5M87_RS00660 (J5M87_00660) 102017..102502 - 486 WP_154607856.1 hypothetical protein -
J5M87_RS09770 102595..103116 - 522 WP_230082343.1 hypothetical protein -
J5M87_RS00670 (J5M87_00670) 103129..103377 - 249 WP_154607855.1 hypothetical protein -
J5M87_RS00675 (J5M87_00675) 103480..104277 - 798 WP_154607854.1 DnaD domain protein -
J5M87_RS00680 (J5M87_00680) 104431..104712 - 282 WP_154607853.1 hypothetical protein -
J5M87_RS00685 (J5M87_00685) 104714..105049 - 336 WP_154607852.1 DNA-binding protein -
J5M87_RS00690 (J5M87_00690) 105059..105253 - 195 WP_154607851.1 hypothetical protein -
J5M87_RS00695 (J5M87_00695) 105247..105402 - 156 WP_154607850.1 hypothetical protein -
J5M87_RS00700 (J5M87_00700) 105399..105722 - 324 WP_154607849.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL 97172..121543 24371


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(18-82)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6618.80 Da        Isoelectric Point: 10.9086

>T197303 WP_068993248.1 NZ_CP072115:c100999-100820 [Streptococcus sp. zg-86]
MPMTQKEMVKLLIANGWTKTKGGKGSHVKMEKQGERPITVPHGELNKYTERGIRKQAGI

Download         Length: 180 bp

>T197303 NZ_CP095923:295781-296107 [Pseudomonas aeruginosa]
ATGAATGACCCCGTGTACTGCCCGGTTCTTGGGTATGACGCGGTGTTGCTTGTCAACATCTCGACTGTCTATCCAGATAA
GTATTTCGATCAGTCATGCATTCTAAAGAAGGGTTGTCATCCCTTTGTTCTGCACGACAGCTGGGTCGTATACCGCGAGG
CAGGCCCTTTCAACCTTGCACGGCTTGAGCAAGGGGTAGCGCAGAAGTCCATCAAGACGCATCAGCCCATCAACGCAGGC
GATTTCACTCGGATTCGGGCAGGCTTCGACATCTCGCCCGACGTCAAAATCAAAGTTGAGCGGTTCATGAGGCAGCACAA
GATTTAG

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16610.55 Da        Isoelectric Point: 3.8741

>AT197303 WP_154607858.1 NZ_CP072115:c100782-100330 [Streptococcus sp. zg-86]
MLVTYPALFYYDDTDGTNVPYFVHFPDIDGSGTQGADIADAMAMASDWLGINLAHYIENGQDLPQPADINSLSLAENDPF
KDDEELRMVYDPNKSFVSMVVVDVAEYLGSQEPIKKTLTIPRWADTLGRELGLNFSQTLTDAIADKKLQA

Download         Length: 453 bp

>AT197303 NZ_CP095923:295152-295709 [Pseudomonas aeruginosa]
GTGATCTTCAGTGAACAGAAAGTGGCTCACATGGCAGCTTTCTTTTTGGCGAGTGCCGAAGGGCCGCTGCCTCATCTCAC
GCTGATCAAACTGCTGTACCTGGCAGACCGAGAGTCGATGGCTCGTTTCGACGTTCCCATGTCGGACGATCGAGCTGTTT
CCATGCCCCATGGGCCTGTCCTTTCCTCGACGCTAGACCTCATCAAGGGGCGTTTGCGCTCTGAGGTTTGGAGCGCTTGG
ATTTCTCCGTTGGTGGATCACGAGGTCCGTCTGGTCCATGACGTGGAGAATTGGGACGATCTGGATGAGTTGAGCCGATC
GGATCGCAGCATTTTGGAATCGGTCTGGCAAGAGTTTGGCCACATGACCAAGTACCAATTGCGGGACTACACCCACCATC
ACATTGGTGAGTGGCACGACCCCCACGGCTCTTCCAGGGACATTGATCCAAAGGATACTTTCATGGCGCTTGGTCAAAGC
GAGGAGCTGGCGGAGATCAAGGCGCGCGATCTTGCTGAGCGCCGTCGGCACGGTAGGAAGCTGTCTGAGTTCATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References