197290

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2147771..2148749 Replicon chromosome
Accession NZ_CP072061
Organism Bacillus mycoides strain JAS06/1

Toxin (Protein)


Gene name spoIISA Uniprot ID J8I6P2
Locus tag J5V93_RS10880 Protein ID WP_002017051.1
Coordinates 2147771..2148511 (+) Length 247 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag J5V93_RS10885 Protein ID WP_000588712.1
Coordinates 2148624..2148749 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5V93_RS10850 (J5V93_10850) 2142873..2143634 + 762 WP_002127420.1 ABC transporter ATP-binding protein -
J5V93_RS10855 (J5V93_10855) 2143740..2144450 + 711 WP_002127421.1 class I SAM-dependent methyltransferase -
J5V93_RS10860 (J5V93_10860) 2144569..2144982 + 414 WP_002012925.1 VOC family protein -
J5V93_RS10865 (J5V93_10865) 2145159..2145791 - 633 WP_002017047.1 type 1 glutamine amidotransferase family protein -
J5V93_RS10870 (J5V93_10870) 2146065..2146541 + 477 WP_002017049.1 MarR family winged helix-turn-helix transcriptional regulator -
J5V93_RS10875 (J5V93_10875) 2146695..2147432 + 738 WP_002032137.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
J5V93_RS10880 (J5V93_10880) 2147771..2148511 + 741 WP_002017051.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
J5V93_RS10885 (J5V93_10885) 2148624..2148749 + 126 WP_000588712.1 hypothetical protein Antitoxin
J5V93_RS10890 (J5V93_10890) 2148825..2149001 + 177 WP_003189253.1 stage II sporulation protein SB -
J5V93_RS10895 (J5V93_10895) 2149022..2149411 - 390 WP_215564340.1 YxeA family protein -
J5V93_RS10900 (J5V93_10900) 2149663..2151132 + 1470 WP_016126945.1 aminoacyl-histidine dipeptidase -
J5V93_RS10905 (J5V93_10905) 2151492..2151641 + 150 WP_002069316.1 hypothetical protein -
J5V93_RS10910 (J5V93_10910) 2152355..2153014 + 660 WP_003189261.1 CatB-related O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-244)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 247 a.a.        Molecular weight: 28512.20 Da        Isoelectric Point: 8.3034

>T197290 WP_002017051.1 NZ_CP072061:2147771-2148511 [Bacillus mycoides]
MTISNIRIGLFILAIVFIVLVFFYWRNEELYEEKKQRIRKTWYGLFITSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIA
FILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPTAFGTMEWHTEEEYTKSLNTFLDSYGEKIGAK
IVVFEAVKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIH
HSYFSK

Download         Length: 741 bp

>T197290 NZ_CP095874:2354826-2355563 [Bacillus sp. PGP15]
GTGATCTCTAACATTCGAATCGGCTTATTTATTTTAGCAATCGTTTTTCTAGTTCTTGTTTTCTTTTACTGGAGAAATGA
AGAGTTGTACGAAGAGAAGAAGCAACGGATTAGAAAGACTTGGTATGGGTTATTTATAGTATCAGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTCACTGCAATGGTTATTTTCGTTGATATTGCATTT
ATTTTAACACCTAATATTTCAGAAATATGGGGAGCGAAATTTAGCGATATCGGCAAGACTGTTCAATCGATAAAAAGATC
ATTAATTGCTTCTAAAGCAAGAGGAGAAATATACACAACAATTATTCAAAATGTGAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAAGACTATACAAAAAGTTTAAACGCATTTTTAGATTCATACGGGGAAAAGATTGGAGCGAAAATT
GTTGTATTTGAATCGGCAAAGGAATTAAATACAAACTTTCGCGGTATCCGCTCGCAATTTAGTACTATCGTTCCATTTGA
ACACATTGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGAATTATACCAGTAAAAATAGTGAGTGATG
TTTTCATTGTTATTGATGGGAAGAAAAATAATCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTACTTTAGTAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT197290 WP_000588712.1 NZ_CP072061:2148624-2148749 [Bacillus mycoides]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT197290 NZ_CP095874:2355676-2355801 [Bacillus sp. PGP15]
GTGATAAAAGATTATGACAATGATTTTTTTAAAGAAGATAATGAAGATGCAACAGATTTCTCGTTAATAAAAGGAGATAC
ATTACAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J8I6P2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References