197288

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 244022..244664 Replicon chromosome
Accession NZ_CP072057
Organism Bacillus mycoides strain JAS12/5

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag J5V73_RS01375 Protein ID WP_000635965.1
Coordinates 244314..244664 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag J5V73_RS01370 Protein ID WP_000004570.1
Coordinates 244022..244309 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5V73_RS01345 (J5V73_01345) 239337..240299 + 963 WP_131248046.1 UV DNA damage repair endonuclease UvsE -
J5V73_RS01350 (J5V73_01350) 240292..240864 - 573 WP_113735921.1 rhomboid family intramembrane serine protease -
J5V73_RS01355 (J5V73_01355) 240957..241316 + 360 WP_088034763.1 holo-ACP synthase -
J5V73_RS01360 (J5V73_01360) 241473..242423 + 951 WP_002091373.1 outer membrane lipoprotein carrier protein LolA -
J5V73_RS01365 (J5V73_01365) 242541..243710 + 1170 WP_088034765.1 alanine racemase -
J5V73_RS01370 (J5V73_01370) 244022..244309 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
J5V73_RS01375 (J5V73_01375) 244314..244664 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
J5V73_RS01380 (J5V73_01380) 244733..246901 + 2169 WP_131248052.1 Tex family protein -
J5V73_RS01385 (J5V73_01385) 246959..247075 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
J5V73_RS01390 (J5V73_01390) 247286..247741 + 456 WP_215576745.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T197288 WP_000635965.1 NZ_CP072057:244314-244664 [Bacillus mycoides]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

>T197288 NZ_CP095873:c3763592-3762672 [Alcaligenes faecalis]
ATGAATCCCCTGCCTGGCACCTTGCCGCTTTTATCCGCCCGGGAGACGCGCTATCTGCAGGCCTGTCTGCCCTTGTCGAC
CGTAGACATCGGTCGTGGCCGACAGGTGGCGGTGCGATGCGCGGGCGACGGTGAGCAATGGGTCGTTTGCTTGCACGGCA
TCGGTTCGGGCTCGGCGTCCTGGTTGCGGGTGGCACAGCAATTGCCACCGGGCCTGCGCTTGCTGGCTTGGGATGCTCCC
GGTTATGGCTTGTCTACTCCTCTGGAAATGGACAAGCCCACGGCGCTGGACTATGCCCGGCGTCTGCAGGAACTGCTGCA
TGTTCTGGAAGTGAAGGATTTTGTGCTGGTCGGGCACTCCTTGGGTGCCTTGATGGCGGGCGCCTATGCCCGTCATCTTG
ATCAGGGAGAGATGCAGGCGTTGTTCCTGATGAGCCCTGCAATTGGGTATGGACGCCCGGGTTTGGAACAGCGCCGTCAG
GCAGTGTGGGATCAGCGTATGGCGCAGGTGGCGTCGGGTGATATGGGCTTGATGGCTCGTCAGCGTCACCAGCGATTGCT
GTCGGAGCAGGCTACTTCCGAAAACCGGGAGTTGGTGTTGTGGATTATGGCCAGTCTGCACCTGGCGGGCTATCAGCAAG
CTGTGCAGATGTTGTGCCAGGAAGACCTGCTAACCTACCTGCCTCTTTCCAGCAGCGTGCCTGTCGCAGTGAGTTGTGGC
GAAGTGGATGTGGTGACAACTCCTGAGGCGTGCGCCGGGGTGGCGCGGGCTTGTTCCCAACATTTACAACTGGTTCCCCA
AGCGGGACATGCCAGTTATGTCGAGCAGCCTGGTGCCATGCTGGAAGCCTTGCAATCTTTGCTGGGCCAGACGCAAGCCT
TGCGTTCCGTGGCCACGACCAGGAGTAGTCATGAGCAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT197288 WP_000004570.1 NZ_CP072057:244022-244309 [Bacillus mycoides]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT197288 NZ_CP095873:c3762682-3761879 [Alcaligenes faecalis]
ATGAGCAGTGAATTGAATAAGAGCGATGCCAGTGCTGACCGTTATACCGTGCCCGCGCTGGAGCGGGGCCTGCTGATTCT
GACCCAGTTCAGCCGGGATCAGCGCACTTTGGGTGCGCCCGAACTGGCGCGACGCCTGGACTTGCCCCGCTCGACCGTGT
TTCGCCTGCTGTCCACGCTGGAAGGCATGGGTTTTGTGGAGCGCACTGAGAATGGCCGTGATTACCGTTTGAGCGTCGGT
GTCTTGCGCCTGGGTTTTGAATACGTGGCCTCCCTGGACGTGACCGAACTGGGCCGTCCGGTGATGGAGCGTTTGTGTGA
GCAGGTGCGTCTGCCCTGCAATCTGGTGGTGCGCGATTTGCGCTCGATTGTGTATGTGTCCCGCATTGCGGCGCCAACCC
CGTTTGCCAGCTCGGTGACGGTAGGGACCCGCTTGCCAGCGCATGCCACAGTGCTGGGCCATGTGCTGCTTAGCCAGCTG
AGCCTGACTGAGTTGAAAGAGCTGTACCCCGAACCGGAACTGGAGCGCTTTACCTCCCATACTCCAGCGGATGTGCCCCA
GCTGTACGAGTTTTGCCAAGCCATCCGCGAACAAGGCTATGCACTGAGCGAGGGCTATTTCGAGTCCACGATCTCGACCA
TTGCGGCCCCTGTGTTCAATGGTGCGGGCAAGGTAGCAGCGGCACTGGGCGTAACCGCCATGGCGGCCAGTTTTGAAGGC
GAGCGTCTGGCCGAGATGATTGCTCAGGTCAAGGCAGCCGCCGCCGAGCTCTCGGAGCTCGTCAGGCATTCCCCCCATAG
TTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References