Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1152751..1153305 Replicon chromosome
Accession NZ_CP072026
Organism Akkermansia muciniphila strain Akk1990

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J5W58_RS04965 Protein ID WP_022198093.1
Coordinates 1152751..1153017 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag J5W58_RS04970 Protein ID WP_215833261.1
Coordinates 1153033..1153305 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5W58_RS04945 (J5W58_04945) 1148499..1150658 + 2160 WP_022198097.1 transglutaminase-like domain-containing protein -
J5W58_RS04950 (J5W58_04950) 1150788..1151315 + 528 WP_232051467.1 gamma carbonic anhydrase family protein -
J5W58_RS04955 (J5W58_04955) 1151335..1151820 + 486 WP_022198095.1 DUF151 domain-containing protein -
J5W58_RS04965 (J5W58_04965) 1152751..1153017 - 267 WP_022198093.1 Txe/YoeB family addiction module toxin Toxin
J5W58_RS04970 (J5W58_04970) 1153033..1153305 - 273 WP_215833261.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J5W58_RS04975 (J5W58_04975) 1153706..1154731 - 1026 WP_102735597.1 hypothetical protein -
J5W58_RS04980 (J5W58_04980) 1155042..1156907 + 1866 WP_022197774.1 SLC13 family permease -
J5W58_RS04985 (J5W58_04985) 1157031..1157264 + 234 WP_094136700.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10655.28 Da        Isoelectric Point: 10.1761

>T197242 WP_022198093.1 NZ_CP072026:c1153017-1152751 [Akkermansia muciniphila]
MKRNIVFAPQAWEDFQFFLGNDRKTCKRILDMIKEIQRTPFDGKGKPEPLRENLSGFWSRRIDSTNRLVYRITETDLELL
QMRYHYGK

Download         Length: 267 bp

>T197242 NZ_CP095843:c2656889-2656782 [Escherichia fergusonii]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10119.59 Da        Isoelectric Point: 7.8643

>AT197242 WP_215833261.1 NZ_CP072026:c1153305-1153033 [Akkermansia muciniphila]
MNTISSTAARQSISKTLAAVLNDREPVRIVNKRLGAVIIMPEDEFNSWQETIYLLKCPANARRLLDGVEALNRRQGTVTK
TVEELEHHSC

Download         Length: 273 bp

>AT197242 NZ_CP095843:2656947-2657001 [Escherichia fergusonii]
CAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References