Detailed information of TA system TA197241

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 1152800..1153354
• Replicon: chromosome
• Accession: NZ_CP072024
• Organism: Akkermansia muciniphila strain Akk2030

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J5W52_RS04965
• Protein ID: WP_022198093.1
• Coordinates: 1152800..1153066 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: J5W52_RS04970
• Protein ID: WP_215833261.1
• Coordinates: 1153082..1153354 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5W52_RS04945 (J5W52_04945)	1148548..1150707	+	2160	WP_022198097.1	transglutaminase-like domain-containing protein	-
J5W52_RS04950 (J5W52_04950)	1150837..1151364	+	528	WP_232051467.1	gamma carbonic anhydrase family protein	-
J5W52_RS04955 (J5W52_04955)	1151384..1151869	+	486	WP_022198095.1	DUF151 domain-containing protein	-
J5W52_RS04965 (J5W52_04965)	1152800..1153066	-	267	WP_022198093.1	Txe/YoeB family addiction module toxin	Toxin
J5W52_RS04970 (J5W52_04970)	1153082..1153354	-	273	WP_215833261.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
J5W52_RS04975 (J5W52_04975)	1153755..1154780	-	1026	WP_102735597.1	hypothetical protein	-
J5W52_RS04980 (J5W52_04980)	1155092..1156957	+	1866	WP_022197774.1	SLC13 family permease	-
J5W52_RS04985 (J5W52_04985)	1157081..1157314	+	234	WP_094136700.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10655.28 Da
• Isoelectric Point: 10.1761

>T197241 WP_022198093.1 NZ_CP072024:c1153066-1152800 [Akkermansia muciniphila]
MKRNIVFAPQAWEDFQFFLGNDRKTCKRILDMIKEIQRTPFDGKGKPEPLRENLSGFWSRRIDSTNRLVYRITETDLELL
QMRYHYGK

Nucleotide

• Length: 267 bp

>T197241 NZ_CP095843:2159200-2159541 [Escherichia fergusonii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCCCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTATGCAAATTGTCGGCGCGTAAACAAAAGCAGGTGCAGGATTTTATTGGGGTAATTGC
GGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10119.59 Da
• Isoelectric Point: 7.8643

>AT197241 WP_215833261.1 NZ_CP072024:c1153354-1153082 [Akkermansia muciniphila]
MNTISSTAARQSISKTLAAVLNDREPVRIVNKRLGAVIIMPEDEFNSWQETIYLLKCPANARRLLDGVEALNRRQGTVTK
TVEELEHHSC

Nucleotide

• Length: 273 bp

>AT197241 NZ_CP095843:c2159205-2159129 [Escherichia fergusonii]
AGTCATGATTACTATTCTCGTGAAATAGGGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT