Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pmenTA/darT(toxin) |
Location | 5518467..5520196 | Replicon | chromosome |
Accession | NZ_CP072011 | ||
Organism | Pseudomonas corrugata strain 3prime |
Toxin (Protein)
Gene name | pmenT | Uniprot ID | A0A8B6UP12 |
Locus tag | C4C32_RS24325 | Protein ID | WP_055137583.1 |
Coordinates | 5518467..5519111 (+) | Length | 215 a.a. |
Antitoxin (Protein)
Gene name | pmenA | Uniprot ID | A0A8B6UP13 |
Locus tag | C4C32_RS24330 | Protein ID | WP_055137582.1 |
Coordinates | 5519108..5520196 (+) | Length | 363 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C4C32_RS24300 (C4C32_24300) | 5514009..5514920 | + | 912 | WP_024780091.1 | restriction endonuclease | - |
C4C32_RS24305 (C4C32_24305) | 5515014..5515568 | + | 555 | WP_208554993.1 | hypothetical protein | - |
C4C32_RS24310 (C4C32_24310) | 5515951..5516310 | - | 360 | WP_053191369.1 | DUF6124 family protein | - |
C4C32_RS24315 (C4C32_24315) | 5516806..5518056 | + | 1251 | WP_024781172.1 | IS256 family transposase | - |
C4C32_RS24320 (C4C32_24320) | 5518137..5518466 | + | 330 | WP_244251413.1 | DarT ssDNA thymidine ADP-ribosyltransferase family protein | - |
C4C32_RS24325 (C4C32_24325) | 5518467..5519111 | + | 645 | WP_055137583.1 | DUF4433 domain-containing protein | Toxin |
C4C32_RS24330 (C4C32_24330) | 5519108..5520196 | + | 1089 | WP_055137582.1 | macro domain-containing protein | Antitoxin |
C4C32_RS24335 (C4C32_24335) | 5520388..5520747 | - | 360 | WP_055137581.1 | DUF6124 family protein | - |
C4C32_RS24340 (C4C32_24340) | 5521230..5521688 | - | 459 | WP_055137580.1 | GNAT family N-acetyltransferase | - |
C4C32_RS24345 (C4C32_24345) | 5521975..5522190 | + | 216 | WP_024780087.1 | DUF1737 domain-containing protein | - |
C4C32_RS24350 (C4C32_24350) | 5522563..5523459 | + | 897 | WP_024780086.1 | HTH-type transcriptional regulator ArgP | - |
C4C32_RS24355 (C4C32_24355) | 5523634..5524116 | + | 483 | WP_033034809.1 | hypothetical protein | - |
C4C32_RS24360 (C4C32_24360) | 5524091..5524606 | + | 516 | WP_024780084.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 5515951..5524606 | 8655 | |
- | flank | IS/Tn | - | - | 5516806..5518056 | 1250 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 215 a.a. Molecular weight: 24929.51 Da Isoelectric Point: 8.4285
>T197238 WP_055137583.1 NZ_CP072011:5518467-5519111 [Pseudomonas corrugata]
MIYSRLNPEKALIWRIVHRDNLPWILDNGLHCANSTVRSSQYVNIGNADLIDKRRTRHVPIAPGGVLSDYVPFYFTPFSV
MMKNIHSGRSVQQRSNDEILILVSSLYLVEQMGFPFVYTNAHAYPDWTDYYSDLANLDQIDWSIIQRRDFKREPDDPRKM
ERYQAEALIHNHLPITGLLGIMCYTDAMKKRIDRDVAARGLTLSVHARPGWYFQ
MIYSRLNPEKALIWRIVHRDNLPWILDNGLHCANSTVRSSQYVNIGNADLIDKRRTRHVPIAPGGVLSDYVPFYFTPFSV
MMKNIHSGRSVQQRSNDEILILVSSLYLVEQMGFPFVYTNAHAYPDWTDYYSDLANLDQIDWSIIQRRDFKREPDDPRKM
ERYQAEALIHNHLPITGLLGIMCYTDAMKKRIDRDVAARGLTLSVHARPGWYFQ
Download Length: 645 bp
>T197238 NZ_CP095843:c1766735-1766358 [Escherichia fergusonii]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGACCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCTGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGAGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGACCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCTGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGAGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA
Antitoxin
Download Length: 363 a.a. Molecular weight: 40827.81 Da Isoelectric Point: 6.4007
>AT197238 WP_055137582.1 NZ_CP072011:5519108-5520196 [Pseudomonas corrugata]
MIRFTQGNLLEAKTEALVNTVNTVGVMGKGIALMFKERFAENYRLYSAACKAREVETGKVHVTAVNELEGPRWIVNFPTK
RHWRSPSQMAWITEGLHDLRRFLIENDVKSVAVPPLGAGNGGLKWPEVREQIVEILSDLDVDVLVFEPSNQYLNISKRSG
VEKLTPARALIAELVRRYWVLGMECSLLEIQKLAWFLERAIEQLPNTENPLNLRFVAHKYGPYANRLEHLLNNLDGSYLH
CDKRISDAGISDVIWFDEGRKAFLQAYLQTEAKEYTRALERTAELIDGFESPFGMELLATVDWLLSQDGISPTVPAVREA
LKHWDGGAGAAARKSKLFDDQALDIALKRLTSSSFRPEVATC
MIRFTQGNLLEAKTEALVNTVNTVGVMGKGIALMFKERFAENYRLYSAACKAREVETGKVHVTAVNELEGPRWIVNFPTK
RHWRSPSQMAWITEGLHDLRRFLIENDVKSVAVPPLGAGNGGLKWPEVREQIVEILSDLDVDVLVFEPSNQYLNISKRSG
VEKLTPARALIAELVRRYWVLGMECSLLEIQKLAWFLERAIEQLPNTENPLNLRFVAHKYGPYANRLEHLLNNLDGSYLH
CDKRISDAGISDVIWFDEGRKAFLQAYLQTEAKEYTRALERTAELIDGFESPFGMELLATVDWLLSQDGISPTVPAVREA
LKHWDGGAGAAARKSKLFDDQALDIALKRLTSSSFRPEVATC
Download Length: 1089 bp
>AT197238 NZ_CP095843:c1767192-1766824 [Escherichia fergusonii]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACAACAACAACGATCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCACTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACAACAACAACGATCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCACTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B6UP12 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A8B6UP13 |