Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 386052..386699 Replicon chromosome
Accession NZ_CP072011
Organism Pseudomonas corrugata strain 3prime

Toxin (Protein)


Gene name vapC Uniprot ID A0A3M3EJ95
Locus tag C4C32_RS01710 Protein ID WP_024778040.1
Coordinates 386052..386468 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A3M3EIH6
Locus tag C4C32_RS01715 Protein ID WP_024778041.1
Coordinates 386469..386699 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4C32_RS01685 (C4C32_01685) 381539..382792 - 1254 WP_055136124.1 methyltransferase -
C4C32_RS01690 (C4C32_01690) 382773..383462 - 690 WP_024778036.1 ABC transporter permease -
C4C32_RS01695 (C4C32_01695) 383459..384154 - 696 WP_024778037.1 ABC transporter permease -
C4C32_RS01700 (C4C32_01700) 384233..384988 - 756 WP_024778038.1 ABC transporter substrate-binding protein -
C4C32_RS01705 (C4C32_01705) 385002..385775 - 774 WP_024778039.1 ABC transporter ATP-binding protein -
C4C32_RS01710 (C4C32_01710) 386052..386468 - 417 WP_024778040.1 tRNA(fMet)-specific endonuclease VapC Toxin
C4C32_RS01715 (C4C32_01715) 386469..386699 - 231 WP_024778041.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
C4C32_RS01720 (C4C32_01720) 386874..387323 + 450 WP_024778042.1 hypothetical protein -
C4C32_RS01725 (C4C32_01725) 387333..387779 - 447 WP_024778043.1 hypothetical protein -
C4C32_RS01730 (C4C32_01730) 387922..388980 - 1059 WP_024778044.1 PDDEXK nuclease domain-containing protein -
C4C32_RS01735 (C4C32_01735) 389220..389627 - 408 WP_024778045.1 hypothetical protein -
C4C32_RS01740 (C4C32_01740) 389693..390022 - 330 WP_208555165.1 DHCW motif cupin fold protein -
C4C32_RS01750 (C4C32_01750) 390325..390597 - 273 WP_024778047.1 oxidative damage protection protein -
C4C32_RS01755 (C4C32_01755) 390594..391661 - 1068 WP_208555166.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 377142..386699 9557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15272.92 Da        Isoelectric Point: 7.2656

>T197237 WP_024778040.1 NZ_CP072011:c386468-386052 [Pseudomonas corrugata]
MIKFMLDTNICIFTIKNKPQMVREAFNLHHGQLCISAVTLMELIYGAEKSCAPERNLAVIEGFCARLEVLPFGYEAAAHT
GMIRAELAKAGKPIGPYDQMIAGHARSLGLIVITNNLKEFERVPGLRTEDWTVAKGPE

Download         Length: 417 bp

>T197237 NZ_CP095843:1610213-1610431 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8543.58 Da        Isoelectric Point: 4.3417

>AT197237 WP_024778041.1 NZ_CP072011:c386699-386469 [Pseudomonas corrugata]
MEQTTLFMSNRSQAVRLPKAVAMPSDVKRVDVIAVGRARIITPAGEAWDSWFDGDTVTADFMTDRDQPADQEREPF

Download         Length: 231 bp

>AT197237 NZ_CP095843:1609812-1610186 [Escherichia fergusonii]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M3EJ95

Antitoxin

Source ID Structure
AlphaFold DB A0A3M3EIH6

References