Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 386052..386699 | Replicon | chromosome |
| Accession | NZ_CP072011 | ||
| Organism | Pseudomonas corrugata strain 3prime | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A0A3M3EJ95 |
| Locus tag | C4C32_RS01710 | Protein ID | WP_024778040.1 |
| Coordinates | 386052..386468 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A3M3EIH6 |
| Locus tag | C4C32_RS01715 | Protein ID | WP_024778041.1 |
| Coordinates | 386469..386699 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C4C32_RS01685 (C4C32_01685) | 381539..382792 | - | 1254 | WP_055136124.1 | methyltransferase | - |
| C4C32_RS01690 (C4C32_01690) | 382773..383462 | - | 690 | WP_024778036.1 | ABC transporter permease | - |
| C4C32_RS01695 (C4C32_01695) | 383459..384154 | - | 696 | WP_024778037.1 | ABC transporter permease | - |
| C4C32_RS01700 (C4C32_01700) | 384233..384988 | - | 756 | WP_024778038.1 | ABC transporter substrate-binding protein | - |
| C4C32_RS01705 (C4C32_01705) | 385002..385775 | - | 774 | WP_024778039.1 | ABC transporter ATP-binding protein | - |
| C4C32_RS01710 (C4C32_01710) | 386052..386468 | - | 417 | WP_024778040.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
| C4C32_RS01715 (C4C32_01715) | 386469..386699 | - | 231 | WP_024778041.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| C4C32_RS01720 (C4C32_01720) | 386874..387323 | + | 450 | WP_024778042.1 | hypothetical protein | - |
| C4C32_RS01725 (C4C32_01725) | 387333..387779 | - | 447 | WP_024778043.1 | hypothetical protein | - |
| C4C32_RS01730 (C4C32_01730) | 387922..388980 | - | 1059 | WP_024778044.1 | PDDEXK nuclease domain-containing protein | - |
| C4C32_RS01735 (C4C32_01735) | 389220..389627 | - | 408 | WP_024778045.1 | hypothetical protein | - |
| C4C32_RS01740 (C4C32_01740) | 389693..390022 | - | 330 | WP_208555165.1 | DHCW motif cupin fold protein | - |
| C4C32_RS01750 (C4C32_01750) | 390325..390597 | - | 273 | WP_024778047.1 | oxidative damage protection protein | - |
| C4C32_RS01755 (C4C32_01755) | 390594..391661 | - | 1068 | WP_208555166.1 | A/G-specific adenine glycosylase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 377142..386699 | 9557 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15272.92 Da Isoelectric Point: 7.2656
>T197237 WP_024778040.1 NZ_CP072011:c386468-386052 [Pseudomonas corrugata]
MIKFMLDTNICIFTIKNKPQMVREAFNLHHGQLCISAVTLMELIYGAEKSCAPERNLAVIEGFCARLEVLPFGYEAAAHT
GMIRAELAKAGKPIGPYDQMIAGHARSLGLIVITNNLKEFERVPGLRTEDWTVAKGPE
MIKFMLDTNICIFTIKNKPQMVREAFNLHHGQLCISAVTLMELIYGAEKSCAPERNLAVIEGFCARLEVLPFGYEAAAHT
GMIRAELAKAGKPIGPYDQMIAGHARSLGLIVITNNLKEFERVPGLRTEDWTVAKGPE
Download Length: 417 bp
>T197237 NZ_CP095843:1610213-1610431 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCGTATGGAAATTCATTCGCTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8543.58 Da Isoelectric Point: 4.3417
>AT197237 WP_024778041.1 NZ_CP072011:c386699-386469 [Pseudomonas corrugata]
MEQTTLFMSNRSQAVRLPKAVAMPSDVKRVDVIAVGRARIITPAGEAWDSWFDGDTVTADFMTDRDQPADQEREPF
MEQTTLFMSNRSQAVRLPKAVAMPSDVKRVDVIAVGRARIITPAGEAWDSWFDGDTVTADFMTDRDQPADQEREPF
Download Length: 231 bp
>AT197237 NZ_CP095843:1609812-1610186 [Escherichia fergusonii]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3M3EJ95 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3M3EIH6 |